Concentration dependent nonlinear K+ and Cl- leak current (Huang et al. 2015)

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Accession:195569
"In their seminal works on squid giant axons, Hodgkin, and Huxley approximated the membrane leak current as Ohmic, i.e., linear, since in their preparation, sub-threshold current rectification due to the influence of ionic concentration is negligible. Most studies on mammalian neurons have made the same, largely untested, assumption. Here we show that the membrane time constant and input resistance of mammalian neurons (when other major voltage-sensitive and ligand-gated ionic currents are discounted) varies non-linearly with membrane voltage, following the prediction of a Goldman-Hodgkin-Katz-based passive membrane model. ..." (see paper for details and more).
Reference:
1 . Huang S, Hong S, De Schutter E (2015) Corrigendum: Non-linear leak currents affect mammalian neuron physiology. Front Cell Neurosci 9:475 [PubMed]
2 . Huang S, Hong S, De Schutter E (2015) Non-linear leak currents affect mammalian neuron physiology. Front Cell Neurosci 9:432 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Cerebellum purkinje cell; Hodgkin-Huxley neuron;
Channel(s): I K,leak; I Cl, leak;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s):
Implementer(s): Huang, Shiwei [shiweihuang at outlook.com]; Hong, Sungho [shhong at oist.jp];
Search NeuronDB for information about:  Cerebellum purkinje cell; I K,leak; I Cl, leak;

Huang S, Hong S, De Schutter E (2015) Non-linear leak currents affect mammalian neuron physiology. Front Cell Neurosci 9:432[PubMed]

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(50 refs)

Huang S, Hong S, De Schutter E (2015) Corrigendum: Non-linear leak currents affect mammalian neuron physiology. Front Cell Neurosci 9:475[PubMed]

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References and models that cite this paper

(0 refs)