Synaptic integration in a model of granule cells (Gabbiani et al 1994)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:19591
We have developed a compartmental model of a turtle cerebellar granule cell consisting of 13 compartments that represent the soma and 4 dendrites. We used this model to investigate the synaptic integration of mossy fiber inputs in granule cells. See reference or abstract at PubMed link below for more information.
Reference:
1 . Gabbiani F, Midtgaard J, Knopfel T (1994) Synaptic integration in a model of cerebellar granule cells. J Neurophysiol 72:999-1009 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule cell;
Channel(s): I Na,t; I L high threshold; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Coincidence Detection; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Gabbiani, F;
Search NeuronDB for information about:  Cerebellum interneuron granule cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I K; I h; I K,Ca;
Granule cell program files for the paper:

Synaptic integration in a model of cerebellar granule cells.
Gabbiani F, Midtgaard J, Knopfel T.
Institut fur Theoretische Physik, ETH-Honggerberg, Zurich, Switzerland.
J Neurophysiol 1994 Aug;72(2):999-1009

Excerpt from abstract:

1. We have developed a compartmental model of a turtle cerebellar granule 
cell consisting of 13 compartments that represent the soma and 4 
dendrites. We used this model to investigate the synaptic integration of 
mossy fiber inputs in granule cells. 
2. The somatic compartment contained six active ionic conductances: 
a sodium conductance with fast activation and inactivation kinetics, 
gNa; a high-voltage-activated calcium conductance, gCa(HVA); a 
delayed potassium conductance, gK(DR); a transient potassium 
conductance, gK(A); a slowly relaxing mixed Na+/K+ conductance 
activating at hyperpolarized membrane potentials, gH, and a 
calcium- and voltage-dependent potassium conductance, gK(Ca). The 
kinetics of these conductances was derived from electrophysiological 
studies in a variety of preparations, including turtle and rat granule 
cells. 
3. In the soma, dynamics of intracellular free Ca2+ was modeled 
by incorporation of a Na+/Ca2+ exchanger, radial diffusion, and binding 
sites for Ca2+. 
4. The model of the turtle granule cell exhibited depolarization-induced
action potential firing with properties closely resembling those seen 
with intracellular recordings in turtle granule cells in vitro. 
... please see the paper for 5 more summary paragraphs.

The model files are configured to reproduce results from the first two
figures when auto-launched.  Press a figure button in the simulation 
control box to see that figure.

See the paper for additional detailed studies that examine the role 
of NMDA receptors in temporal summation of excitatory synaptic 
potentials and GABAA receptors role in coincidence detection; Golgi
cell inhibition on mossy fiber to granule cell transmission and more...


Loading data, please wait...