CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)

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Accession:19696
The model shows how the experimentally observed increase in the dendritic density of Ih and IA could have a major role in constraining the temporal integration window for the main CA1 synaptic inputs.
Reference:
1 . Migliore M (2003) On the Integration of Subthreshold Inputs from Perforant Path and Schaffer Collaterals in Hippocampal CA1 Pyramidal Neurons. J Comput Neurosci 14:185-192 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Coincidence Detection; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; I Na,t; I A; I K; I h; Glutamate;
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sc-pp
readme.txt
h.mod *
kadist.mod
kaprox.mod *
kdrca1.mod *
na3.mod *
nax.mod *
fig4.hoc
mosinit.hoc
n160_mod.nrn *
                            
NEURON mod files from the paper:
M. Migliore, On the integration of subthreshold inputs 
from Perforant Path and Schaffer collaterals in hippocampal 
CA1 pyramidal neurons, J.Comput. Neurosci., in press (2002).

The model shows how the experimentally observed increase in the
dendritic density of Ih and IA could have a major role in 
constraining the temporal integration window for the main CA1 
synaptic inputs. The main effect is demonstrated here for a 
subset of conditions from fig.4 of the paper,
which is the result of long simulations.
With the fig4.hoc file three series of simulations will run.
In all cases, two synapses in a proximal and distal compartment
will be activated at latencies between -30 and 18ms.
The three cases differ for the dendritic distribution of gKA and Ih.  
- full model, with gKA and Ih increasing with distance from soma
- uniform KA, with constant gKA and increasing Ih.
- uniform KA and Ih, with constant gKA and constant Ih.
The top simulation panel shows the membrane potential at the soma
during each simulation.
In the bottom panel a circle will be shown at the end
of each simulation. The circle will be filled if an Action Potential
was generated by the simulation.
The simulations are intended to demonstrate how
the temporal window for summation of the two inputs to elicit an AP
is affected by the experimentally observed dendritic gKA and Ih distribution.

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui fig4.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
fig4.hoc 
will open the simulation window.

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it

Bugs and fixes:
04 July 2003  -  M. Migliore
A bug in the vhalfl variable declaration in h.mod
required a change of ghd in fig4.hoc (from 0.0002 to 0.0005) 
to obtain the same results. 



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