Leech heart interneuron network model (Hill et al 2001, 2002)

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Accession:19698
We have created a computational model of the timing network that paces the heartbeat of the medicinal leech, Hirudo medicinalis. In the intact nerve cord, segmental oscillators are mutually entrained to the same cycle period. Although experiments have shown that the segmental oscillators are coupled by inhibitory coordinating interneurons, the underlying mechanisms of intersegmental coordination have not yet been elucidated. To help understand this coordination, we have created a simple computational model with two variants: symmetric and asymmetric. See references for more details. Biologically realistic network models with two, six, and eight cells and a tutorial are available at the links to Calabrese's web site below.
References:
1 . Hill AA, Masino MA, Calabrese RL (2002) Model of intersegmental coordination in the leech heartbeat neuronal network. J Neurophysiol 87:1586-602 [PubMed]
2 . Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL (2001) A model of a segmental oscillator in the leech heartbeat neuronal network. J Comput Neurosci 10:281-302 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart interneuron;
Channel(s): I Na,p; I Na,t; I K; I h; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Bursting; Oscillations; Spatio-temporal Activity Patterns; Tutorial/Teaching; Action Potentials; Invertebrate;
Implementer(s): Hill, Andrew A [aavhill at yahoo.com];
Search NeuronDB for information about:  I Na,p; I Na,t; I K; I h; I Calcium; I Potassium;
  
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HillEtAl2001_2
Calabrese
HN-net
leech-libraries
readme.txt
                            
This is the readme for the GENESIS models associated with the papers:

1 . Hill AA, Masino MA, Calabrese RL (2002) Model of intersegmental
coordination in the leech heartbeat neuronal network. J Neurophysiol
87:1586-602 [PubMed]

2 . Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL (2001) A model of
a segmental oscillator in the leech heartbeat neuronal network. J
Comput Neurosci 10:281-302

These models were previously available at a Calabrese lab web
site. The files are now available here where the contents of these tar
files are present in these folders

HN-NET.tar          HN-net/
leech-libraries.tar leech-libraries/
tutorial.tar        Calabrese/

Please refer to the readme's in the folders for more information.

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