Leech heart interneuron network model (Hill et al 2001, 2002)

 Download zip file 
Help downloading and running models
Accession:19698
We have created a computational model of the timing network that paces the heartbeat of the medicinal leech, Hirudo medicinalis. In the intact nerve cord, segmental oscillators are mutually entrained to the same cycle period. Although experiments have shown that the segmental oscillators are coupled by inhibitory coordinating interneurons, the underlying mechanisms of intersegmental coordination have not yet been elucidated. To help understand this coordination, we have created a simple computational model with two variants: symmetric and asymmetric. See references for more details. Biologically realistic network models with two, six, and eight cells and a tutorial are available at the links to Calabrese's web site below.
Reference:
1 . Hill AA, Masino MA, Calabrese RL (2002) Model of intersegmental coordination in the leech heartbeat neuronal network. J Neurophysiol 87:1586-602 [PubMed]
2 . Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL (2001) A model of a segmental oscillator in the leech heartbeat neuronal network. J Comput Neurosci 10:281-302 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart interneuron;
Channel(s): I Na,p; I Na,t; I K; I h; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Bursting; Oscillations; Spatio-temporal Activity Patterns; Tutorial/Teaching; Action Potentials; Invertebrate;
Implementer(s): Hill, Andrew A [aavhill at yahoo.com];
Search NeuronDB for information about:  I Na,p; I Na,t; I K; I h; I Calcium; I Potassium;
  
/
HillEtAl2001_2
Calabrese
HN-net
leech-libraries
readme.txt
                            
This is the readme for the GENESIS models associated with the papers:

1 . Hill AA, Masino MA, Calabrese RL (2002) Model of intersegmental
coordination in the leech heartbeat neuronal network. J Neurophysiol
87:1586-602 [PubMed]

2 . Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL (2001) A model of
a segmental oscillator in the leech heartbeat neuronal network. J
Comput Neurosci 10:281-302

These models were previously available at a Calabrese lab web
site. The files are now available here where the contents of these tar
files are present in these folders

HN-NET.tar          HN-net/
leech-libraries.tar leech-libraries/
tutorial.tar        Calabrese/

Please refer to the readme's in the folders for more information.

Hill AA, Masino MA, Calabrese RL (2002) Model of intersegmental coordination in the leech heartbeat neuronal network. J Neurophysiol 87:1586-602[PubMed]

References and models cited by this paper

References and models that cite this paper

Angstadt JD, Calabrese RL (1989) A hyperpolarization-activated inward current in heart interneurons of the medicinal leech. J Neurosci 9:2846-57 [PubMed]

Angstadt JD, Calabrese RL (1991) Calcium currents and graded synaptic transmission between heart interneurons of the leech. J Neurosci 11:746-59 [PubMed]

Bower JM, Beeman D (1998) The Book Of Genesis: Exploring Realistic Neural Models With The General Neural Simulation System

Cang J, Friesen WO (2000) Sensory modification of leech swimming: rhythmic activity of ventral stretch receptors can change intersegmental phase relationships. J Neurosci 20:7822-9 [PubMed]

Di Prisco GV, Wallen P, Grillner S (1990) Synaptic effects of intraspinal stretch receptor neurons mediating movement-related feedback during locomotion. Brain Res 530:161-6 [PubMed]

Friesen WO, Pearce RA (1993) Mechanisms of intersegmental coordination in leech locomotion Semin Neurosci 5:41-47

Grillner S, Ekeberg S, El Manira A, Lansner A, Parker D, Tegner J, Wallen P (1998) Intrinsic function of a neuronal network - a vertebrate central pattern generator. Brain Res Brain Res Rev 26:184-97 [PubMed]

Grillner S, Matsushima T, Wadden T, Tegner J, El Manira A, Wallen P (1993) The neurophysiological bases of undulatory locomotion in vertebrates Semin Neurosci 5:17-27

Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL (2001) A model of a segmental oscillator in the leech heartbeat neuronal network. J Comput Neurosci 10:281-302 [Journal] [PubMed]

   Leech heart interneuron network model (Hill et al 2001, 2002) [Model]

Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Ikeda K, Wiersma CAG (1964) Autogenic rhythmicity in the abdominal ganglion of the crayfish: the control of swimmeret movements Comp Biochem Physiol 12:107-115

Jezzini SH, Hill AAV, Calabrese RL (2000) Dynamic activity of a coordinating fiber with two initiation sites Soc Neurosci Abstr 164:1

Kotaleski JH, Grillner S, Lansner A (1999) Neural mechanisms potentially contributing to the intersegmental phase lag in lamprey.I. Segmental oscillations dependent on reciprocal inhibition. Biol Cybern 81:317-30 [PubMed]

Lu J, Dalton JF, Stokes DR, Calabrese RL (1997) Functional role of Ca2+ currents in graded and spike-mediated synaptic transmission between leech heart interneurons. J Neurophysiol 77:1779-94 [Journal] [PubMed]

Masino MA, Calabrese RL (2002) Phase relationships between segmentally organized oscillators in the leech heartbeat pattern generating network. J Neurophysiol 87:1572-85 [Journal] [PubMed]

Masino MA, Calabrese RL (2002) Period differences between segmental oscillators produce intersegmental phase differences in the leech heartbeat timing network. J Neurophysiol 87:1603-15 [Journal] [PubMed]

Matsushima T, Grillner S (1990) Intersegmental co-ordination of undulatory movements--a "trailing oscillator" hypothesis. Neuroreport 1:97-100 [PubMed]

Matsushima T, Grillner S (1992) Neural mechanisms of intersegmental coordination in lamprey: local excitability changes modify the phase coupling along the spinal cord. J Neurophysiol 67:373-88 [Journal] [PubMed]

Murchison D, Chrachri A, Mulloney B (1993) A separate local pattern-generating circuit controls the movements of each swimmeret in crayfish. J Neurophysiol 70:2620-31 [Journal] [PubMed]

Olsen OH, Calabrese RL (1996) Activation of intrinsic and synaptic currents in leech heart interneurons by realistic waveforms. J Neurosci 16:4958-70 [PubMed]

Opdyke CA, Calabrese RL (1994) A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leech. J Comp Physiol [A] 175:781-9 [PubMed]

Peterson EL (1983) Generation and coordination of heartbeat timing oscillation in the medicinal leech. II. Intersegmental coordination. J Neurophysiol 49:627-38 [Journal] [PubMed]

Peterson EL (1983) Generation and coordination of heartbeat timing oscillation in the medicinal leech. I. Oscillation in isolated ganglia. J Neurophysiol 49:611-26 [Journal] [PubMed]

Peterson EL, Calabrese RL (1982) Dynamic analysis of a rhythmic neural circuit in the leech Hirudo medicinalis. J Neurophysiol 47:256-71 [Journal] [PubMed]

Sigvardt KA (1993) Intersegmental coordination in the lamprey central pattern generator for locomotion Semin Neurosci 5:3-15

Simon TW, Opdyke CA, Calabrese RL (1992) Modulatory effects of FMRF-NH2 on outward currents and oscillatory activity in heart interneurons of the medicinal leech. J Neurosci 12:525-37 [PubMed]

Skinner FK, Kopell N, Mulloney B (1997) How does the crayfish swimmeret system work? Insights from nearest-neighbor coupled oscillator models. J Comput Neurosci 4:151-60 [Journal] [PubMed]

Skinner FK, Mulloney B (1998) Intersegmental coordination in invertebrates and vertebrates. Curr Opin Neurobiol 8:725-32 [PubMed]

Skinner FK, Mulloney B (1998) Intersegmental coordination of limb movements during locomotion: mathematical models predict circuits that drive swimmeret beating. J Neurosci 18:3831-42 [PubMed]

Tunstall MJ, Sillar KT (1993) Physiological and developmental aspects of intersegmental coordination in Xenopus embryos and tadpoles Semin Neurosci 5:29-40

Wadden T, Hellgren J, Lansner A, Grillner S (1997) Intersegmental coordination in the lamprey: simulations using a network model without segmental boundaries Biol Cybern 76:1-9

Wallen P, Ekeberg O, Lansner A, Brodin L, Traven H, Grillner S (1992) A computer-based model for realistic simulations of neural networks. II. The segmental network generating locomotor rhythmicity in the lamprey. J Neurophysiol 68:1939-50 [Journal] [PubMed]

Wallen P, Williams TL (1984) Fictive locomotion in the lamprey spinal cord in vitro compared with swimming in the intact and spinal animal. J Physiol 347:225-39 [PubMed]

Williams TL, Sigvardt KA, Kopell N, Ermentrout GB, Remler MP (1990) Forcing of coupled nonlinear oscillators: studies of intersegmental coordination in the lamprey locomotor central pattern generator. J Neurophysiol 64:862-71 [Journal] [PubMed]

Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [Journal] [PubMed]

   Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013) [Model]

(35 refs)

Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL (2001) A model of a segmental oscillator in the leech heartbeat neuronal network. J Comput Neurosci 10:281-302[PubMed]

References and models cited by this paper

References and models that cite this paper

Abbott LF, Marder E (1998) Modeling small networks. Methods in Neuronal Modeling: From Ions to Networks, Second Edition, Koch C:Segev I, ed. pp.361

Angstadt JD, Calabrese RL (1989) A hyperpolarization-activated inward current in heart interneurons of the medicinal leech. J Neurosci 9:2846-57 [PubMed]

Angstadt JD, Calabrese RL (1991) Calcium currents and graded synaptic transmission between heart interneurons of the leech. J Neurosci 11:746-59 [PubMed]

Arbas EA, Calabrese RL (1984) Rate modification in the heartbeat central pattern generator of the medicinal leech J Comp Physiol 155:783-794

Arbas EA, Calabrese RL (1987) Slow oscillations of membrane potential in interneurons that control heartbeat in the medicinal leech. J Neurosci 7:3953-60

Booth V, Rinzel J, Kiehn O (1997) Compartmental model of vertebrate motoneurons for Ca2+-dependent spiking and plateau potentials under pharmacological treatment. J Neurophysiol 78:3371-85 [Journal] [PubMed]

Boroffka I, Hamp R (1969) Topographie des Kreislaufsystems und Zirkulation bei Hirudo medicinalis Zeitschrift Fur Morphologie Der Tiere 64:59-76

Bower JM, Beeman D (1998) The Book Of Genesis: Exploring Realistic Neural Models With The General Neural Simulation System

Brodfuehrer PD, Debski EA, O'Gara BA, Friesen WO (1995) Neuronal control of leech swimming. J Neurobiol 27:403-18 [PubMed]

Calabrese RL (1980) Control of multiple impulse-initiation sites in a leech interneuron. J Neurophysiol 44:878-96 [Journal] [PubMed]

Calabrese RL, Angstadt JD, Arbas EA (1989) A neural oscillator based on reciprocal inhibition Perspectives in Neural Systems and Behavior, Carew TJ:Kelley D, ed. pp.33

Cohen AH, Ermentrout GB, Kiemel T, Kopell N, Sigvardt KA, Williams TL (1992) Modelling of intersegmental coordination in the lamprey central pattern generator for locomotion. Trends Neurosci 15:434-8 [PubMed]

Cymbalyuk GS, Calabrese RL (2000) Oscillatory behaviors in pharmacologically isolated heart interneurons from the medicinal leech Neurocomputing 32:97-104

De Schutter E, Angstadt JD, Calabrese RL (1993) A model of graded synaptic transmission for use in dynamic network simulations. J Neurophysiol 69:1225-35 [Journal] [PubMed]

Friesen WO, Pearce RA (1993) Mechanisms of intersegmental coordination in leech locomotion Semin Neurosci 5:41-47

Grillner S (1999) Bridging the gap - from ion channels to networks and behaviour. Curr Opin Neurobiol 9:663-9

Grillner S, Wallen P (1980) Does the central pattern generation for locomotion in lamprey depend on glycine inhibition? Acta Physiol Scand 110:103-5

Grillner S, Wallen P, Brodin L, Lansner A (1991) Neuronal network generating locomotor behavior in lamprey: circuitry, transmitters, membrane properties, and simulation. Annu Rev Neurosci 14:169-99 [PubMed]

Hille B (1992) Potassium channels and chloride channels Ionic Channels of Excitable Membrane, Hille B, ed. pp.115

Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Ikeda K, Wiersma CAG (1964) Autogenic rhythmicity in the abdominal ganglion of the crayfish: the control of swimmeret movements Comp Biochem Physiol 12:107-115

Ivanov AI, Calabrese RL (1999) Correlation of presynaptic intracelluar Ca2+ concentration with homosynaptic plasticity between leech inhibitory heart interneurons Soc Neurosci Abstr 25:658

Kopell N, Ermentrout GB (1988) Coupled oscillators and the design of central pattern generators Math Biosci 90:87-109

Krahl B, Zerbst-boroffka I (1983) Blood pressure in the leech, Hirudo Medicinalis J Exp Biol 107:163-168

Lu J, Dalton JF, Stokes DR, Calabrese RL (1997) Functional role of Ca2+ currents in graded and spike-mediated synaptic transmission between leech heart interneurons. J Neurophysiol 77:1779-94 [Journal] [PubMed]

Maranto AR (1982) Neuronal mapping: a photooxidation reaction makes Lucifer yellow useful for electron microscopy. Science 217:953-5

Marder E, Calabrese RL (1996) Principles of rhythmic motor pattern generation. Physiol Rev 76:687-717 [PubMed]

Masino MA, Calabrese RL (1999) Differences in inherent cycle periods between coupled segmental oscillators can produce phase differences in the leech heartbeat central pattern generator Soc Neurosci Abstr 25:659

Mulloney B, Skinner FK, Namba H, Hall WM (1998) Intersegmental coordination of swimmeret movements: mathematical models and neural circuits. Ann N Y Acad Sci 860:266-80

Murchison D, Chrachri A, Mulloney B (1993) A separate local pattern-generating circuit controls the movements of each swimmeret in crayfish. J Neurophysiol 70:2620-31 [Journal] [PubMed]

Nadim F, Calabrese RL (1997) A slow outward current activated by FMRFamide in heart interneurons of the medicinal leech. J Neurosci 17:4461-72 [PubMed]

Nadim F, Olsen OH, De Schutter E, Calabrese RL (1995) Modeling the leech heartbeat elemental oscillator. I. Interactions of intrinsic and synaptic currents. J Comput Neurosci 2:215-35 [Journal] [PubMed]

Namba H, Mulloney B (1999) Coordination of limb movements: three types of intersegmental interneurons in the swimmeret system and their responses to changes in excitation. J Neurophysiol 81:2437-50 [Journal]

Nicholls J, Wallace BG (1978) Modulation of transmission at an inhibitory synapse in the central nervous system of the leech. J Physiol 281:157-70

Nicholls J, Wallace BG (1978) Quantal analysis of transmitter release at an inhibitory synapse in the central nervous system of the leech. J Physiol 281:171-85

Nicholls JG, Baylor DA (1968) Specific modalities and receptive fields of sensory neurons in CNS of the leech. J Neurophysiol 31:740-56 [Journal] [PubMed]

Olsen OH, Calabrese RL (1996) Activation of intrinsic and synaptic currents in leech heart interneurons by realistic waveforms. J Neurosci 16:4958-70 [PubMed]

Olsen OH, Nadim F, Calabrese RL (1995) Modeling the leech heartbeat elemental oscillator. II. Exploring the parameter space. J Comput Neurosci 2:237-57 [Journal] [PubMed]

Opdyke CA, Calabrese RL (1994) A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leech. J Comp Physiol [A] 175:781-9 [PubMed]

Paul DH, Mulloney B (1986) Intersegmental coordination of swimmeret rhythms in isolated nerve cords of crayfish J Comp Physiol 158:215-224

Peterson EL (1983) Generation and coordination of heartbeat timing oscillation in the medicinal leech. II. Intersegmental coordination. J Neurophysiol 49:627-38 [Journal] [PubMed]

Pinsky PF, Rinzel J (1994) Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1:39-60 [Journal] [PubMed]

   CA3 pyramidal cell: rhythmogenesis in a reduced Traub model (Pinsky, Rinzel 1994) [Model]

Roberts A, Soffe SR, Wolf ES, Yoshida M, Zhao FY (1998) Central circuits controlling locomotion in young frog tadpoles. Ann N Y Acad Sci 860:19-34

Schmidt J, Calabrese RL (1992) Evidence that acetylcholine is an inhibitory transmitter of heart interneurons in the leech. J Exp Biol 171:329-47

Schweighofer N, Doya K, Kawato M (1999) Electrophysiological properties of inferior olive neurons: A compartmental model. J Neurophysiol 82:804-17 [Journal] [PubMed]

Simon TW, Opdyke CA, Calabrese RL (1992) Modulatory effects of FMRF-NH2 on outward currents and oscillatory activity in heart interneurons of the medicinal leech. J Neurosci 12:525-37 [PubMed]

Simon TW, Schmidt J, Calabrese RL (1994) Modulation of high-threshold transmission between heart interneurons of the medicinal leech by FMRF-NH2. J Neurophysiol 71:454-66 [Journal]

Skinner FK, Kopell N, Marder E (1994) Mechanisms for oscillation and frequency control in reciprocally inhibitory model neural networks. J Comput Neurosci 1:69-87 [Journal] [PubMed]

Skinner FK, Kopell N, Mulloney B (1997) How does the crayfish swimmeret system work? Insights from nearest-neighbor coupled oscillator models. J Comput Neurosci 4:151-60 [Journal] [PubMed]

Stein PS (1971) Intersegmental coordination of swimmeret motoneuron activity in crayfish. J Neurophysiol 34:310-8 [Journal] [PubMed]

Thompson WJ, Stent GS (1976) Neuronal control of heartbeat in the medicinal leech. III. Synaptic relations of the heart interneurons J Comp Physiol 111:309-333

Tolbert LP, Calabrese RL (1985) Anatomical analysis of contacts between identified neurons that control heartbeat in the leech Hirudo medicinalis Cell Tissue Res 242:257-267

Wadden T, Hellgren J, Lansner A, Grillner S (1997) Intersegmental coordination in the lamprey: simulations using a network model without segmental boundaries Biol Cybern 76:1-9

Wang XJ, Rinzel J (1992) Alternating and synchronous rhythms in reciprocally inhibitory model neurons Neural Comput 4:84-97

Channell P, Fuwape I, Neiman AB, Shilnikov AL (2009) Variability of bursting patterns in a neuron model in the presence of noise. J Comput Neurosci 27:527-42 [Journal] [PubMed]

   Reduced leech heart interneuron (Channell et al. 2009) [Model]

Cymbalyuk G, Shilnikov A (2005) Coexistence of Tonic Spiking Oscillations in a Leech Neuron Model J Comp Neurosci 18:255-263 [Journal]

Gabbiani F, Krapp HG (2006) Spike-frequency adaptation and intrinsic properties of an identified, looming-sensitive neuron. J Neurophysiol 96:2951-62 [Journal] [PubMed]

   Leaky integrate-and-fire model of spike frequency adaptation in the LGMD (Gabbiani and Krapp 2006) [Model]

Hill AA, Masino MA, Calabrese RL (2002) Model of intersegmental coordination in the leech heartbeat neuronal network. J Neurophysiol 87:1586-602 [Journal] [PubMed]

   Leech heart interneuron network model (Hill et al 2001, 2002) [Model]

Nowotny T, Levi R, Selverston AI (2008) Probing the dynamics of identified neurons with a data-driven modeling approach. PLoS ONE 3:e2627 [Journal] [PubMed]

   Data-driven, HH-type model of the lateral pyloric (LP) cell in the STG (Nowotny et al. 2008) [Model]

Olypher AV, Calabrese RL (2007) Using constraints on neuronal activity to reveal compensatory changes in neuronal parameters. J Neurophysiol 98:3749-58 [Journal] [PubMed]

   Activity constraints on stable neuronal or network parameters (Olypher and Calabrese 2007) [Model]

Susswein AJ, Hurwitz I, Thorne R, Byrne JH, Baxter DA (2002) Mechanisms underlying fictive feeding in aplysia: coupling between a large neuron with plateau potentials activity and a spiking neuron. J Neurophysiol 87:2307-23 [Journal] [PubMed]

Tobin AE, Calabrese RL (2006) Endogenous and half-center bursting in morphologically inspired models of leech heart interneurons. J Neurophysiol 96:2089-106 [Journal] [PubMed]

Tobin AE, Van Hooser SD, Calabrese RL (2006) Creation and reduction of a morphologically detailed model of a leech heart interneuron. J Neurophysiol 96:2107-20 [Journal] [PubMed]

(63 refs)