NEURON mod files from the paper:
Maciej T. Lazarewicz, Michele Migliore, Giorgio A. Ascoli (2002)
A new bursting model of CA3 pyramidal cell physiology suggests multiple
locations for spike initiation, Biosystems, 67:129-137.
The model shows how using a CA1-like distribution of active
dendritic conductances in a CA3 morphology results in
dendritic initiation of spikes during a burst.
The effect is demonstrated here in a demo
simulation reproducing the results in Fig.2 of the paper.
The ca3_paper.hoc simulation will show the membrane potential at the soma,
the time course of membrane potential with distance from soma
for three different paths spanning the entire neuron lenght,
and a movie of the neuron depolarization (a NEURON Shape Plot)
during a burst elicited by a short (1nA, 5ms) somatic current pulse.
The simulation is best appreciated using a black background for the graphs.
To invert the background/foreground color edit
the lib/nrn.def (windows) or share/nrn/lib/nrn.defaults (unix) file
in the NEURON home directory, and change the two lines
This change will affect all future graphs, so
do not forget to reset the values to their original values
if you do not like graphs with a black background and white lines.
Under unix systems:
to compile the mod files use the command
and run the simulation with the command
Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
will run the simulation.
Questions on how to use this model with NEURON should be directed to
Maciej Lazarewicz (mailto:firstname.lastname@example.org)
Questions on how to use the mod files should be directed to
Michele Migliore (email@example.com).
Thanks to Leif Finkel and Elliot Menschik, UPENN,
for valuable discussions on the model.
Bugs and fixes:
03 July 2003 - M. Migliore
Fixed a bug in the vhalfl and ehd variable declaration in KhdM01.mod
19 Sept 2007 - T. Morse
Set 0 diam points in soma in ca3a.geo to 1e-9 so modelview works.