CA1 interneuron: K currents (Lien et al 2002)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:20015
NEURON mod files for slow and fast K-DR, and K-A potassium currents in inhibitory interneurones of stratum oriens-alveus of the hippocampal CA1 region.
Reference:
1 . Lien CC, Martina M, Schultz JH, Ehmke H, Jonas P (2002) Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol 538:405-19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 interneuron oriens alveus GABA cell;
Channel(s): I A; I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 interneuron oriens alveus GABA cell; I A; I K; I Potassium;
TITLE KA
: K-A current for hippocampal interneurons from Lien et al (2002)
: M.Migliore Jan. 2003

NEURON {
	SUFFIX ka
	USEION k READ ek WRITE ik
	RANGE  gbar
	GLOBAL minf, hinf, htau, mtau
}

PARAMETER {
	gbar = 0.0002   	(mho/cm2)	
								
	celsius
	ek		(mV)            : must be explicitly def. in hoc
	v 		(mV)
	a0h=0.17
	vhalfh=-105
	q10=3
	hmin=5
}


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(pS) = (picosiemens)
	(um) = (micron)
} 

ASSIGNED {
	ik 		(mA/cm2)
	minf 		mtau (ms)
	hinf	 	htau (ms)
}
 

STATE { m h}

BREAKPOINT {
        SOLVE states METHOD cnexp
	ik = gbar*m*h*(v - ek)
} 

INITIAL {
	trates(v)
	m=minf  
	h=hinf  
}

DERIVATIVE states {   
        trates(v)      
        m' = (minf-m)/mtau
        h' = (hinf-h)/htau
}

PROCEDURE trates(v) {  
	LOCAL qt
        qt=q10^((celsius-23)/10)
        minf = (1/(1 + exp(-(v+41.4)/26.6)))^4
	mtau=0.5/qt
        hinf = 1/(1 + exp((v+78.5)/6))
	htau = a0h*(v-vhalfh)/qt
	if (htau<hmin/qt) {htau=hmin/qt}
}


Loading data, please wait...