CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)

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We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
1 . Poirazi P, Brannon T, Mel BW (2003a) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-987 [PubMed]
2 . Poirazi P, Brannon T, Mel BW (2003b) Pyramidal Neuron as Two-Layer Neural Network. Neuron 37:989-999 [PubMed]
3 . Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model Neuron 37 Online:1-20
4 . Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Depression; Delay;
Implementer(s): Poirazi, Panayiota [poirazi at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; GabaB; NMDA; Glutamate; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
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// mosinit.hoc for mswin and unix version of Poirazi et al model. 6/22/04 TMM

objref box

// debug statements below remind me that new auto-launch starts up with
// current directory (working directory) set to wherever mosinit.hoc is.
// system("pwd")
// print "press return"
// system("read a")

if (unix_mac_pc() ==1 ) { // note if your sys has stdlib.h and string.h this will work however
			  // NEURON's mswin shell comes without these.  If cygwin is added to
			  // your mswin system though you will receive these extra items.
	system("cd ../lib; gcc -o newshiftsyn newshiftsyn.c -Ilib -lm")

if (unix_mac_pc() ==1 || unix_mac_pc() ==3 ) {
	// system("cd lib; gcc -o newshiftsyn newshiftsyn.c -Ilib -lm")
	objref box
	box=new VBox()
		xlabel("Sample Runs")
		xbutton("hyperpolarization-current", "unix_hyper_cur()")
		xbutton("Hofman traces", "unix_spike_atten_hof()")
		xbutton("Back Propagating APs", "unix_spike_atten_bpap()")
	box.intercept(0)"Numerical Experiments")
} else  {
	print "not configured for mac yet"
	print "press return"

proc unix_hyper_cur() {
	chdir("..")	// back to one directory below root for other buttons to work

proc unix_spike_atten_hof() {
	chdir("..")	// back to one directory below root for other buttons to work

proc unix_spike_atten_bpap() {
	chdir("..")	// back to one directory below root for other buttons to work

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