CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)

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Accession:20212
We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
References:
1 . Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-87 [PubMed]
2 . Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network. Neuron 37:989-99 [PubMed]
3 . Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model Neuron 37 Online:1-20
4 . Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Depression; Delay;
Implementer(s): Poirazi, Panayiota [poirazi at imbb.forth.gr];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; NMDA; Glutamate; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
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CA1_multi
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
gabab-gabaa-uniform-ratio.hoc *
n123.hoc *
nmda-ampa-ratio.hoc *
oblique-paths.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
                            
// This function makes a list with oblique branches in addition to 
// the primary list in apical-tip-list.hoc 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref apical_tip_list_addendum
apical_tip_list_addendum=new SectionList()


//    SISTER of apical_dendrite[3]   is apical_dendrite[2]    
//    SISTER of apical_dendrite[34]  is apical_dendrite[33]   
//    SISTER of apical_dendrite[37]  is apical_dendrite[36]   
//    SISTER of apical_dendrite[40]  is apical_dendrite[39]
//    SISTER of apical_dendrite[45]  is apical_dendrite[44]
//    SISTER of apical_dendrite[54]  is apical_dendrite[53] 
//    SISTER of apical_dendrite[68]  is apical_dendrite[67] 
//    SISTER of apical_dendrite[111] is apical_dendrite[110] 
//    SISTER of apical_dendrite[115] is apical_dendrite[114] 
//    SISTER of apical_dendrite[118] is apical_dendrite[117] 

  apical_dendrite[2]    apical_tip_list_addendum.append()  // 1 degree      69.9821  microns from soma
  apical_dendrite[33]   apical_tip_list_addendum.append()  // 2 degrees    177.4831 (vertical distance)
  apical_dendrite[36]   apical_tip_list_addendum.append()  // 2 degree     189.0447 
  apical_dendrite[37]   apical_tip_list_addendum.append()  // 2 degrees    180.5792 
  apical_dendrite[39]   apical_tip_list_addendum.append()  // 1 degree      83.7030
  apical_dendrite[40]   apical_tip_list_addendum.append()  // 1 degreee    102.6654
  apical_dendrite[44]   apical_tip_list_addendum.append()  // 0 degree     172.7760 
  apical_dendrite[47]   apical_tip_list_addendum.append()  // 0 degree.    177.4980
  apical_dendrite[53]   apical_tip_list_addendum.append()  // 3 degrees    202.8910
  apical_dendrite[54]   apical_tip_list_addendum.append()  // 3 degrees    190.3009
  apical_dendrite[67]   apical_tip_list_addendum.append()  // 2 degrees    289.5367   
  apical_dendrite[110]  apical_tip_list_addendum.append()  // 1 degree      98.7392
  apical_dendrite[114]  apical_tip_list_addendum.append()  // 1 degree     123.9962
  apical_dendrite[117]  apical_tip_list_addendum.append()  // 0 degree      67.6363

//  forsec apical_tip_list_addendum {
//    apical_tip_list.append()
//  }

/* Make a shape graph with the additional oblique branches

objref apical_tip_list_addendum_shape
color_index = 3
apical_tip_list_addendum_shape=new Shape()
apical_tip_list_addendum_shape.color_list(apical_tip_list_addendum,color_index)
apical_tip_list_addendum_shape.printfile("apical-tip-list-addendum.eps")
*/

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