CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)

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Accession:20212
We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
References:
1 . Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-87 [PubMed]
2 . Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network. Neuron 37:989-99 [PubMed]
3 . Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model Neuron 37 Online:1-20
4 . Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Depression; Delay;
Implementer(s): Poirazi, Panayiota [poirazi at imbb.forth.gr];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; NMDA; Glutamate; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
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CA1_multi
mechanism
not-currently-used
cad.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
h.mod *
hha_old.mod *
hha2.mod *
kadist.mod *
kaprox.mod *
kca.mod *
km.mod *
nap.mod *
nmda.mod *
somacar.mod *
mosinit.hoc *
mosinit.hoc.old *
                            
TITLE  Na persistent channel
: used in distal oblique dendrites to assist Ca spike initiation  
: a typo in the exponential function was pointed out by Michele Migliore and
: corrected by Yiota Poirazi on December 4th, 2003
NEURON {
	SUFFIX nap
	USEION na READ ena WRITE ina
        RANGE  gnabar,vhalf, K

}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}

PARAMETER {                         : parameters that can be entered when function is called in cell-setup 
        dt (ms) 
	v (mV)
        ena = 50           (mV)     : Na reversal potential  (reset in cell-setup.hoc)
	K = 4.5            (1)      : slope of steady state variable
:	gnabar = 0.001e-2 (mho/cm2) : suggested conductance, 1 percent of the transient Na current
	gnabar = 0                  : initialized conductance
	vhalf  = -50.4    (mV)      : half potential
}	

STATE { n }

ASSIGNED {
	ina (mA/cm2)
}

INITIAL {
:	SOLVE states
}

BREAKPOINT {
	SOLVE states
	ina = gnabar*n*n*n*(v-ena)
}

PROCEDURE states() {     : exact when v held constant; integrates over dt step

:        n = 1 / (1 + (exp(vhalf - v))/K) : steady state value !!!typo in the exponential function!!!

        n = 1 / (1 + (exp(vhalf - v)/K)) : steady state value
        VERBATIM
        return 0;
        ENDVERBATIM
}
















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