CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)

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Accession:20212
We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
References:
1 . Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-87 [PubMed]
2 . Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network. Neuron 37:989-99 [PubMed]
3 . Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model Neuron 37 Online:1-20
4 . Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Depression; Delay;
Implementer(s): Poirazi, Panayiota [poirazi at imbb.forth.gr];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; GabaB; NMDA; Glutamate; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
/
CA1_multi
template
BasalPath.hoc *
EPSPTuning.hoc *
ExperimentControl.hoc *
load_templates.hoc *
load_templates.hoc~
ObliquePath.hoc *
RangeRef.hoc *
SynapseBand.hoc *
                            
// This template is used to create a band of sections by
// randomly selecting sections within a specified region (in
// interval [lo hi]). Sections can be selected with or without
// repetition and synapses can be allocated at predifined
// locations along these sections 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu


objref synapse_band_shape, gaba_band_shape
synapse_band_shape=new Shape() // shape graph to plot AMPA and NMDA synapses
gaba_band_shape=new Shape()    // shape graph to plot GABA_A and GABA_B synapses

begintemplate SynapseBand

public pick_and_salloc, pick_and_SALLOC, pick, pick_and_remove, pick_and_SALLOC_GABAa, pick_and_SALLOC_GABAb
objref all_secs, secs_in_band, selected_secs, rnum, ltmp
strdef exec_str

proc init () {
  all_secs=$o1     // list of all sections to choose from
  lo=$2            // minimum distance from soma
  hi=$3            // maximum distance from soma
  actual_res=$4    // obsolete. Used only if more than one synapses are to be placed at a specific location
  desired_res=$5   // obsolete. Used only if more than one synapses are to be placed at a specific location
  PID=$6           // random number generator seed 

//  print "choosing sections that are between ", lo, " and ", hi, " microns from the soma"	

  secs_in_band=new List()
  if (PID < 0) {
     PID=-PID       // if PID < 0 choose sections branchwise
     sprint(exec_str,"choose_secs_branchwise(%s,%s,%g,%g,%g,%g)", all_secs,secs_in_band,lo,hi,actual_res,desired_res)
  } else {  	
     sprint(exec_str,"choose_secs(%s,%s,%g,%g,%g,%g)", all_secs,secs_in_band,lo,hi,actual_res,desired_res)
  }
  execute1(exec_str)  // use ../lib/choose-secs.hoc to choose sections and store them in "secs_in_band"

  rnum=new Random(PID)
}

proc cdto() {    // Access a given section
  ltmp=secs_in_band.object(num)
  access ltmp.section_ref.sec
//  print secname(), "accessed by SynapseBand.pick()"
}

proc cdto_rm() { // Remove the section just accessed
  ltmp=secs_in_band.object(num)
  access ltmp.section_ref.sec
//  print secname(), " accessed by SynapseBand.pick(). cdto_rm() is removing it."
  secs_in_band.remove(num)
}

proc pick() {  //randomly (uniformly) pick a section in band and access it
  num=rnum.uniform(0,secs_in_band.count()-1)
  cdto(num)
}

proc pick_and_remove() { //randomly (uniform) pick a section in band, access and remove it 
    num=rnum.uniform(0,secs_in_band.count()-1)
    cdto_rm(num)
}

proc pick_and_salloc() { // randomly pick a section in band, access it and allocate a synapse (AMPA or NMDA) on it
  pick()
  sprint(exec_str,"salloc(%s,%s,%g)", $o1,$o2,ltmp.range_ref)     // in ../lib/salloc.hoc
  execute1(exec_str)
  sprint(exec_str,"synapse_band_shape.point_mark(%s,%d)", $o1,$3) // make a shape graph and print a 
  execute1(exec_str)						  // dot at the location of the synapse 
}

proc pick_and_SALLOC() { // same as above but made to work with both AMPA/NMDA and GABA synapses (not used)
  pick()
  sprint(exec_str,"SALLOC(%s,%s,%g,%d)", $o1,$o2,ltmp.range_ref,$4) // in ../lib/salloc.hoc
  execute1(exec_str)
  sprint(exec_str,"synapse_band_shape.point_mark(%s,%d)", $o1,$3)
  execute1(exec_str)
}

proc pick_and_SALLOC_GABAa() { // Used if only GABA_A synapses will be allocated
  pick()
  sprint(exec_str,"SALLOC_GABAa(%s,%g,%d,%g)", $o1,ltmp.range_ref, $3, $4)   // in ../lib/salloc.hoc 
  execute1(exec_str)
  sprint(exec_str,"gaba_band_shape.point_mark(%s,%d)", $o1, $2)
  execute1(exec_str)
}

proc pick_and_SALLOC_GABAb() {  // Used if only GABA_B synapses will be allocated
  pick()
  sprint(exec_str,"SALLOC_GABAb(%s,%g,%d,%g)", $o1,ltmp.range_ref, $3, $4)   // in ../lib/salloc.hoc
  execute1(exec_str)
  sprint(exec_str,"gaba_band_shape.point_mark(%s,%d)", $o1,$2)
  execute1(exec_str)
}

endtemplate SynapseBand


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