A dendritic disinhibitory circuit mechanism for pathway-specific gating (Yang et al. 2016)


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Accession:206227
"While reading a book in a noisy café, how does your brain ‘gate in’ visual information while filtering out auditory stimuli? Here we propose a mechanism for such flexible routing of information flow in a complex brain network (pathway-specific gating), tested using a network model of pyramidal neurons and three classes of interneurons with connection probabilities constrained by data. We find that if inputs from different pathways cluster on a pyramidal neuron dendrite, a pathway can be gated-on by a disinhibitory circuit motif. ..."
Reference:
1 . Yang GR, Murray JD, Wang XJ (2016) A dendritic disinhibitory circuit mechanism for pathway-specific gating. Nat Commun 7:12815 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Connectionist Network; Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal intratelencephalic L2-5 cell;
Channel(s):
Gap Junctions:
Receptor(s): Gaba; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: Python (web link to model);
Model Concept(s): Action Selection/Decision Making; Synaptic Plasticity; Information transfer; Rate-coding model neurons;
Implementer(s): Yang, Guangyu Robert ;
Search NeuronDB for information about:  Neocortex V1 pyramidal intratelencephalic L2-5 cell; NMDA; Gaba;
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