Cortex-Basal Ganglia-Thalamus network model (Kumaravelu et al. 2016)

 Download zip file 
Help downloading and running models
Accession:206232
" ... We developed a biophysical network model comprising of the closed loop cortical-basal ganglia-thalamus circuit representing the healthy and parkinsonian rat brain. The network properties of the model were validated by comparing responses evoked in basal ganglia (BG) nuclei by cortical (CTX) stimulation to published experimental results. A key emergent property of the model was generation of low-frequency network oscillations. Consistent with their putative pathological role, low-frequency oscillations in model BG neurons were exaggerated in the parkinsonian state compared to the healthy condition. ..."
Reference:
1 . Kumaravelu K, Brocker DT, Grill WM (2016) A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease. J Comput Neurosci 40:207-29 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia; Thalamus; Neocortex; Subthalamic Nucleus;
Cell Type(s): Hodgkin-Huxley neuron; Abstract Izhikevich neuron;
Channel(s): I K; I Calcium; I Sodium; I L high threshold; I T low threshold; I_AHP;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Deep brain stimulation; Parkinson's; Activity Patterns; Oscillations;
Implementer(s): Kumaravelu, Karthik [kk192 at duke.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I L high threshold; I T low threshold; I K; I Sodium; I Calcium; I_AHP; Gaba; Glutamate;
  
/
KumaraveluEtAl2016
readme.txt
run_simulate_network_model.q
simulate_network_model.m
                            
This is the readme for the matlab model associated with the paper:

Kumaravelu K, Brocker DT, Grill WM (2016) A biophysical model of the
cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model
of Parkinson's disease. J Comput Neurosci 40:207-29

This model was contributed by K. Kumaravelu.

The model was run on the Duke Shared Cluster Resource with the
supplied q file.

20161212 Karthik Kumaravelu supplied a minor typo update where some
multiplicative forms (t_vec-t_d_...) were removed from bi-exponential
synaptic functions.

Loading data, please wait...