CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
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CA1_multi
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell_+spine.hoc
cell_+spine_multi.hoc
cell_div2.hoc
cell_mul2.hoc
cell-analysis.hoc *
cell-analysis_div2.hoc
cell-analysis_mul2.hoc
n123.hoc *
oblique-paths.hoc
peri-trunk-list.hoc *
soma-list.hoc *
                            
// Make a set of lists, each containing the oblique sections
// that form a continuous path: starting from the section attached 
// to the trunk and ending at the apical tip section. 

objref pl[1150],opl[1150]
plcount=0
pl[plcount]=new SectionList()

apical_dendrite[0] pl[plcount].append()
apical_dendrite[1] pl[plcount].append()
apical_dendrite[2] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[0] pl[plcount].append()
apical_dendrite[1] pl[plcount].append()
apical_dendrite[3] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[4] pl[plcount].append()
apical_dendrite[5] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[6] pl[plcount].append()
apical_dendrite[7] pl[plcount].append()
apical_dendrite[8] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[6] pl[plcount].append()
apical_dendrite[7] pl[plcount].append()
apical_dendrite[9] pl[plcount].append()
apical_dendrite[10] pl[plcount].append()
apical_dendrite[11] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[6] pl[plcount].append()
apical_dendrite[7] pl[plcount].append()
apical_dendrite[9] pl[plcount].append()
apical_dendrite[10] pl[plcount].append()
apical_dendrite[12] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[6] pl[plcount].append()
apical_dendrite[7] pl[plcount].append()
apical_dendrite[9] pl[plcount].append()
apical_dendrite[13] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[14] pl[plcount].append()
apical_dendrite[116] pl[plcount].append()
apical_dendrite[117] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])


plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[14] pl[plcount].append()
apical_dendrite[116] pl[plcount].append()
apical_dendrite[118] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])


plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[16] pl[plcount].append()
apical_dendrite[17] pl[plcount].append()
apical_dendrite[18] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[16] pl[plcount].append()
apical_dendrite[17] pl[plcount].append()
apical_dendrite[19] pl[plcount].append()
apical_dendrite[20] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[16] pl[plcount].append()
apical_dendrite[17] pl[plcount].append()
apical_dendrite[19] pl[plcount].append()
apical_dendrite[21] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[23] pl[plcount].append()
apical_dendrite[24] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[27] pl[plcount].append()
apical_dendrite[28] pl[plcount].append()
apical_dendrite[29] pl[plcount].append()
apical_dendrite[30] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[27] pl[plcount].append()
apical_dendrite[28] pl[plcount].append()
apical_dendrite[29] pl[plcount].append()
apical_dendrite[31] pl[plcount].append()
apical_dendrite[32] pl[plcount].append()
apical_dendrite[33] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[27] pl[plcount].append()
apical_dendrite[28] pl[plcount].append()
apical_dendrite[29] pl[plcount].append()
apical_dendrite[31] pl[plcount].append()
apical_dendrite[32] pl[plcount].append()
apical_dendrite[34] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[27] pl[plcount].append()
apical_dendrite[28] pl[plcount].append()
apical_dendrite[29] pl[plcount].append()
apical_dendrite[31] pl[plcount].append()
apical_dendrite[35] pl[plcount].append()
apical_dendrite[36] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[27] pl[plcount].append()
apical_dendrite[28] pl[plcount].append()
apical_dendrite[29] pl[plcount].append()
apical_dendrite[31] pl[plcount].append()
apical_dendrite[35] pl[plcount].append()
apical_dendrite[37] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[27] pl[plcount].append()
apical_dendrite[28] pl[plcount].append()
apical_dendrite[38] pl[plcount].append()
apical_dendrite[39] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[27] pl[plcount].append()
apical_dendrite[28] pl[plcount].append()
apical_dendrite[38] pl[plcount].append()
apical_dendrite[40] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[42] pl[plcount].append()
apical_dendrite[43] pl[plcount].append()
apical_dendrite[44] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[42] pl[plcount].append()
apical_dendrite[43] pl[plcount].append()
apical_dendrite[45] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[46] pl[plcount].append()
apical_dendrite[47] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[48] pl[plcount].append()
apical_dendrite[49] pl[plcount].append()
apical_dendrite[50] pl[plcount].append()
apical_dendrite[51] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[48] pl[plcount].append()
apical_dendrite[49] pl[plcount].append()
apical_dendrite[50] pl[plcount].append()
apical_dendrite[52] pl[plcount].append()
apical_dendrite[53] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[48] pl[plcount].append()
apical_dendrite[49] pl[plcount].append()
apical_dendrite[50] pl[plcount].append()
apical_dendrite[52] pl[plcount].append()
apical_dendrite[54] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[48] pl[plcount].append()
apical_dendrite[49] pl[plcount].append()
apical_dendrite[55] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[56] pl[plcount].append()
apical_dendrite[57] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[58] pl[plcount].append()
apical_dendrite[59] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[60] pl[plcount].append()
apical_dendrite[61] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[62] pl[plcount].append()
apical_dendrite[63] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[62] pl[plcount].append()
apical_dendrite[63] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[65] pl[plcount].append()
apical_dendrite[66] pl[plcount].append()
apical_dendrite[67] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])


plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[65] pl[plcount].append()
apical_dendrite[66] pl[plcount].append()
apical_dendrite[68] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[69] pl[plcount].append()
apical_dendrite[70] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[71] pl[plcount].append()
apical_dendrite[72] pl[plcount].append()
apical_dendrite[73] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[71] pl[plcount].append()
apical_dendrite[72] pl[plcount].append()
apical_dendrite[74] pl[plcount].append()
apical_dendrite[75] pl[plcount].append()
apical_dendrite[76] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[71] pl[plcount].append()
apical_dendrite[72] pl[plcount].append()
apical_dendrite[74] pl[plcount].append()
apical_dendrite[75] pl[plcount].append()
apical_dendrite[77] pl[plcount].append()
apical_dendrite[78] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[71] pl[plcount].append()
apical_dendrite[72] pl[plcount].append()
apical_dendrite[74] pl[plcount].append()
apical_dendrite[75] pl[plcount].append()
apical_dendrite[77] pl[plcount].append()
apical_dendrite[79] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[71] pl[plcount].append()
apical_dendrite[72] pl[plcount].append()
apical_dendrite[74] pl[plcount].append()
apical_dendrite[80] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[81] pl[plcount].append()
apical_dendrite[82] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[83] pl[plcount].append()
apical_dendrite[84] pl[plcount].append()
apical_dendrite[85] pl[plcount].append()
apical_dendrite[86] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[83] pl[plcount].append()
apical_dendrite[84] pl[plcount].append()
apical_dendrite[85] pl[plcount].append()
apical_dendrite[87] pl[plcount].append()
apical_dendrite[88] pl[plcount].append()
apical_dendrite[89] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[83] pl[plcount].append()
apical_dendrite[84] pl[plcount].append()
apical_dendrite[85] pl[plcount].append()
apical_dendrite[87] pl[plcount].append()
apical_dendrite[88] pl[plcount].append()
apical_dendrite[90] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[83] pl[plcount].append()
apical_dendrite[84] pl[plcount].append()
apical_dendrite[85] pl[plcount].append()
apical_dendrite[87] pl[plcount].append()
apical_dendrite[91] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[83] pl[plcount].append()
apical_dendrite[84] pl[plcount].append()
apical_dendrite[92] pl[plcount].append()
apical_dendrite[93] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[83] pl[plcount].append()
apical_dendrite[84] pl[plcount].append()
apical_dendrite[92] pl[plcount].append()
apical_dendrite[94] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[95] pl[plcount].append()
apical_dendrite[96] pl[plcount].append()
apical_dendrite[97] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[95] pl[plcount].append()
apical_dendrite[96] pl[plcount].append()
apical_dendrite[98] pl[plcount].append()
apical_dendrite[99] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[95] pl[plcount].append()
apical_dendrite[96] pl[plcount].append()
apical_dendrite[98] pl[plcount].append()
apical_dendrite[100] pl[plcount].append()
apical_dendrite[101] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[95] pl[plcount].append()
apical_dendrite[96] pl[plcount].append()
apical_dendrite[98] pl[plcount].append()
apical_dendrite[100] pl[plcount].append()
apical_dendrite[102] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[104] pl[plcount].append()
apical_dendrite[105] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[41] pl[plcount].append()
apical_dendrite[107] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[26] pl[plcount].append()
apical_dendrite[108] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[26] pl[plcount].append()
apical_dendrite[109] pl[plcount].append()
apical_dendrite[110] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[26] pl[plcount].append()
apical_dendrite[109] pl[plcount].append()
apical_dendrite[111] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[22] pl[plcount].append()
apical_dendrite[112] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[15] pl[plcount].append()
apical_dendrite[113] pl[plcount].append()
apical_dendrite[114] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[15] pl[plcount].append()
apical_dendrite[113] pl[plcount].append()
apical_dendrite[115] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[64] pl[plcount].append()
apical_dendrite[106] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])

for i=0,1000 {
if (section_exists("apical_dendrite",119+i*2)) {
plcount=plcount+1
pl[plcount]=new SectionList()
apical_dendrite[dendr] pl[plcount].append()
apical_dendrite[119+i*2] pl[plcount].append()
apical_dendrite[120+i*2] pl[plcount].append()
opl[plcount]=new ObliquePath(pl[plcount])
}
}

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