CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
// This function is used to balance the membrane potential to v_init (= -70 mV)
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

proc current_balance() {

 // print "Note: This does not account for non-specific ion currents.\n"

  finitialize($1)
  fcurrent()

  printf("Balancing each compartment to %d mV\n", $1)

  forall {
      for (x) {
        if (ismembrane("na_ion") && ismembrane("ca_ion") && ismembrane("Ca_ion") && (ismembrane("k_ion"))) {
            e_pas(x)=(ina(x)+ik(x)+ica(x)+iCa(x)+g_pas(x)*v(x))/g_pas(x) 
        } else if (ismembrane("na_ion") && ismembrane("ca_ion") && (ismembrane("k_ion"))){
            e_pas(x)=(ina(x)+ik(x)+ica(x)+g_pas(x)*v(x))/g_pas(x) 
        } else if (ismembrane("na_ion") && (ismembrane("k_ion"))) {
            e_pas(x)=(ina(x)+ik(x)+g_pas(x)*v(x))/g_pas(x)
          //printf("Section %s ina: %g ik: %g\n", secname(), ina(x), ik(x))
          //psection()
        } else {
          print "simply assigning v(x)"
          e_pas(x)=v(x)
        }
      fcurrent()
    }
  }
}

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