CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Mullner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
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CA1_multi
mechanism
previously used
ampa.mod *
cad.mod
cagk.mod *
cal.mod *
calH.mod *
cat.mod
cldif.mod
d3.mod *
gabaA_Cl.mod
h.mod *
hha_old.mod *
hha2.mod *
kadist.mod *
kaprox.mod *
kca.mod *
km.mod *
nap.mod *
nmda.mod *
                            
TITLE  H-current that uses Na ions

NEURON {
	SUFFIX h
        RANGE  gbar,vhalf, K, taun, ninf, g  
	USEION na READ ena WRITE ina      
:	NONSPECIFIC_CURRENT i
}

UNITS {
	(um) = (micrometer)
	(mA) = (milliamp)
	(uA) = (microamp)
	(mV) = (millivolt)
	(pmho) = (picomho)
	(mmho) = (millimho)
}

INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}

PARAMETER {              : parameters that can be entered when function is called in cell-setup
        dt             (ms)
	v              (mV)
        ena    = 50    (mV)
        eh     = -10   (mV)
	K      = 8.5   (mV)
	gbar   = 0     (mho/cm2)  : initialize conductance to zero
	vhalf  = -90   (mV)       : half potential
}	


STATE {                : the unknown parameters to be solved in the DEs
	n
}

ASSIGNED {             : parameters needed to solve DE
	ina (mA/cm2)
	ninf
	taun (ms)
	g
}

        


INITIAL {               : initialize the following parameter using states()
	states()	
	n = ninf
	g = gbar*n
	ina = g*(v-eh)
}


BREAKPOINT {
	SOLVE h METHOD derivimplicit
	g = gbar*n
	ina = g*(v-eh)  
}

DERIVATIVE h {
	states()
        n' = (ninf - n)/taun
}

PROCEDURE states() {  
 
 	if (v > -30) {
	   taun = 1
	} else {
           taun = 2*(1/(exp((v+145)/-17.5)+exp((v+16.8)/16.5)) + 5) :h activation tau

	}  
         ninf = 1 - (1 / (1 + exp((vhalf - v)/K)))                  :steady state value
}




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