CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
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CA1_multi
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell_+spine.hoc
cell_+spine_multi.hoc
cell_div2.hoc
cell_mul2.hoc
cell-analysis.hoc *
cell-analysis_div2.hoc
cell-analysis_mul2.hoc
n123.hoc *
oblique-paths.hoc
peri-trunk-list.hoc *
soma-list.hoc *
                            
// This function makes a list with all sections NOT on the apical trunk 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref apical_non_trunk_list
apical_non_trunk_list=new SectionList()

forsec "apical" {
   skip = 0
   ifsec apical_trunk_list { skip=1 }
   if (!skip) {
    apical_non_trunk_list.append()
  }
}

/* Make a graph with all non-trunk sections

objref apical_non_trunk_list_shape
apical_non_trunk_list_shape=new Shape()
color_index = 3
apical_non_trunk_list_shape.color_list(apical_non_trunk_list,color_index)
apical_non_trunk_list_shape.printfile("apical-non-trunk-list.eps")
*/

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