Cerebellum granule cell FHF (Dover et al. 2016)

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Accession:206267
"Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell's unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Nav)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Nav inactivation, distal axonal Navs show little FHF association or FHF requirement for high-frequency transmission, velocity and waveforms of conducting action potentials. ...'
Reference:
1 . Dover K, Marra C, Solinas S, Popovic M, Subramaniyam S, Zecevic D, D'Angelo E, Goldfarb M (2016) FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nat Commun 7:12895 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon; Dendrite;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule cell;
Channel(s): I A; I Calcium; I K; I K,Ca; I M; I Na,p; I Na,t; I Potassium; I Sodium; Kir;
Gap Junctions:
Receptor(s): AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Solinas, Sergio [solinas at unipv.it]; Subramaniyam, Sathyaa [sakthisathyaa at gmail.com]; D'Angelo, Egidio [dangelo at unipv.it]; Goldfarb, Mitchell goldfarb at genectr.hunter.cuny.edu];
Search NeuronDB for information about:  Cerebellum interneuron granule cell; AMPA; NMDA; Gaba; I Na,p; I Na,t; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Kir;
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GrC_FHF_ModelDB
images
README.html
AmpaCOD.mod
GRC_CA.mod *
GRC_CALC.mod *
GRC_GABA.mod *
GRC_KA.mod *
GRC_KCA.mod *
GRC_KIR.mod *
GRC_KM.mod
GRC_KV.mod *
GRC_LKG1.mod *
GRC_LKG2.mod *
GRC_LKG3.mod
GRC_NA.mod
Grc_sine.mod
NmdaS.mod
Pregen.mod *
CClamp_soma.ses
ComPanel.hoc
Fig5.ses
Grc_Cell.hoc
helper_procedures.hoc
Ina.ses
KOFHF.DAPF.slowalfabeta.REV5.30.2016.ses
modComPanel.hoc
mosinit.hoc
Parametri.hoc
Start.hoc
WTFHF.DAPF.slowalfabeta.REV5.30.2016.ses
                            
objectvar save_window_, rvp_
objectvar scene_vector_[7]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{
save_window_ = new Graph(0)
save_window_.size(88,329,-80,21)
scene_vector_[2] = save_window_
{save_window_.view(88, -80, 240, 100, 612, 257, 648, 200)}
graphList[1].append(save_window_)
save_window_.save_name("graphList[1].")
save_window_.addvar("Soma Vm (mV)", "GrC[0].soma.v( 0.5 )", 1, 1, 0.8, 0.9, 2)
}
{
save_window_ = new Graph(0)
save_window_.size(77,88,-70,50)
scene_vector_[3] = save_window_
{save_window_.view(77, -70, 10, 120, 611, 517, 300, 200)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addvar("Soma Vm (mV)", "GrC[0].soma.v( 0.5 )", 1, 3, 0.653035, 1.00543, 2)
save_window_.addexpr("Axon 7 um", "GrC[0].axon[3].v(.5)", 3, 1, 0.653035, 1.00064, 2)
save_window_.addexpr("Axon 69 um", "GrC[0].axon[29].v(.5)", 8, 1, 0.659425, 1.00064, 2)
save_window_.addexpr("PF 129 um", "GrC[0].pf[252].v(1.0)", 5, 1, 0.65623, 0.991054, 2)
save_window_.addexpr("PF 429 um", "GrC[0].pf[292].v(1.0)", 7, 1, 0.659425, 0.98147, 2)
save_window_.addexpr("PF 729 um", "GrC[0].pf[322].v(1.0)", 6, 1, 0.66262, 0.98147, 2)
save_window_.addexpr("PF 1129 um", "GrC[0].pf[352].v(1.0)", 2, 1, 0.672204, 0.852077, 2)
}
{
save_window_ = new Graph(0)
save_window_.size(230.405,243.555,-70,50)
scene_vector_[4] = save_window_
{save_window_.view(230, -70, 13, 120, 971, 517, 300, 200)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addvar("Soma Vm (mV)", "GrC[0].soma.v( 0.5 )", 1, 3, 0.694569, 0.98147, 2)
save_window_.addexpr("Axon 7 um", "GrC[0].axon[3].v(.5)", 3, 1, 0.704153, 0.98147, 2)
save_window_.addexpr("Axon 69 um", "GrC[0].axon[29].v(.5)", 8, 1, 0.704153, 0.986262, 2)
save_window_.addexpr("PF 129 um", "GrC[0].pf[252].v(1.0)", 5, 1, 0.707348, 0.967093, 2)
save_window_.addexpr("PF 429 um", "GrC[0].pf[292].v(1.0)", 7, 1, 0.710543, 0.957508, 2)
save_window_.addexpr("PF 729 um", "GrC[0].pf[322].v(1.0)", 6, 1, 0.716933, 0.957508, 2)
save_window_.addexpr("PF 1129 um", "GrC[0].pf[352].v(1.0)", 2, 1, 0.713738, 0.81853, 2)
}
{
save_window_ = new Graph(0)
save_window_.size(81.9768,88.0242,-37,10)
scene_vector_[6] = save_window_
{save_window_.view(81.9768, -37, 6.04749, 47, 612, 786, 300.48, 200.32)}
graphList[1].append(save_window_)
save_window_.save_name("graphList[1].")
// The section area in um2 is:
pf310_area_um2 = Granule[0].pf[310].L * 3.14 * Granule[0].pf[310].diam
print pf310_area_um2
// In the GRC_NA and GRC_KV ina and iKV are set to have unit: mA/cm2
// The conversion factor to go from mA to pA is 1e9, from um2 to cm2 1e-8
// The conversion factor to go from mA/cm2 to pA is:
cf = pf310_area_um2*1e-8*1e9
save_window_.addexpr("pf 310 INa (pA)","GrC[0].pf[310].ina_GRC_NA(.5)*cf", 3, 1, 0.665815, 0.991054, 2)
save_window_.addexpr("pf 310 IK (pA)","GrC[0].pf[310].ik_GRC_KV(.5)*cf", 2, 1, 0.66262, 0.986262, 2)
}
objectvar scene_vector_[1]
{doNotify()}

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