Cerebellum granule cell FHF (Dover et al. 2016)

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Accession:206267
"Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell's unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Nav)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Nav inactivation, distal axonal Navs show little FHF association or FHF requirement for high-frequency transmission, velocity and waveforms of conducting action potentials. ...'
Reference:
1 . Dover K, Marra C, Solinas S, Popovic M, Subramaniyam S, Zecevic D, D'Angelo E, Goldfarb M (2016) FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nat Commun 7:12895 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon; Dendrite;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I A; I Calcium; I K; I K,Ca; I M; I Na,p; I Na,t; I Potassium; I Sodium; Kir;
Gap Junctions:
Receptor(s): AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Solinas, Sergio [solinas at unipv.it]; Subramaniyam, Sathyaa [sakthisathyaa at gmail.com]; D'Angelo, Egidio [dangelo at unipv.it]; Goldfarb, Mitchell goldfarb at genectr.hunter.cuny.edu];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; AMPA; NMDA; Gaba; I Na,p; I Na,t; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Kir;
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GrC_FHF_ModelDB
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README.html
AmpaCOD.mod
GRC_CA.mod *
GRC_CALC.mod *
GRC_GABA.mod *
GRC_KA.mod *
GRC_KCA.mod *
GRC_KIR.mod *
GRC_KM.mod
GRC_KV.mod *
GRC_LKG1.mod *
GRC_LKG2.mod *
GRC_LKG3.mod
GRC_NA.mod
Grc_sine.mod
NmdaS.mod
Pregen.mod *
CClamp_soma.ses
ComPanel.hoc
Fig5.ses
Grc_Cell.hoc
helper_procedures.hoc
Ina.ses
KOFHF.DAPF.slowalfabeta.REV5.30.2016.ses
modComPanel.hoc
mosinit.hoc
Parametri.hoc
Start.hoc
WTFHF.DAPF.slowalfabeta.REV5.30.2016.ses
                            
TITLE Cerebellum Granule Cell Model

COMMENT
        KDr channel
	Gutfreund parametrization
   
	Author: A. Fontana
	Last revised: 12.12.98
ENDCOMMENT

NEURON { 
	SUFFIX GRC_KV 
	USEION k READ ek WRITE ik 
	RANGE gkbar, ik, g, alpha_n, beta_n 
	RANGE Aalpha_n, Kalpha_n, V0alpha_n
	RANGE Abeta_n, Kbeta_n, V0beta_n
	RANGE n_inf, tau_n 
} 
 
UNITS { 
	(mA) = (milliamp) 
	(mV) = (millivolt) 
} 
 
PARAMETER { 
	:Kbeta_n = -0.0125 (/mV)
	
	Aalpha_n = -0.01 (/ms-mV)
	Kalpha_n = -10 (mV)
	V0alpha_n = -25 (mV)
	Abeta_n = 0.125 (/ms)
	
	Kbeta_n = -80 (mV)
	V0beta_n = -35 (mV)
	v (mV)  
	gkbar= 0.003 (mho/cm2) : 0.0015
	ek = -84.69 (mV) 
	celsius = 30 (degC) 
} 

STATE { 
	n 
} 

ASSIGNED { 
	ik (mA/cm2) 
	n_inf 
	tau_n (ms) 
	g (mho/cm2) 
	alpha_n (/ms) 
	beta_n (/ms) 
} 
 
INITIAL { 
	rate(v) 
	n = n_inf 
} 
 
BREAKPOINT { 
	SOLVE states METHOD derivimplicit 
	g = gkbar*n*n*n*n 
	ik = g*(v - ek) 
	alpha_n = alp_n(v) 
	beta_n = bet_n(v) 
} 
 
DERIVATIVE states { 
	rate(v) 
	n' =(n_inf - n)/tau_n 
} 
 
FUNCTION alp_n(v(mV))(/ms) { LOCAL Q10
	Q10 = 3^((celsius-6.3(degC))/10(degC)) 
	alp_n = Q10*Aalpha_n*linoid(v-V0alpha_n, Kalpha_n)
} 
 
FUNCTION bet_n(v(mV))(/ms) { LOCAL Q10
	Q10 = 3^((celsius-6.3(degC))/10(degC)) 
	bet_n = Q10*Abeta_n*exp((v-V0beta_n)/Kbeta_n) 
} 
 
PROCEDURE rate(v (mV)) {LOCAL a_n, b_n 
	TABLE n_inf, tau_n 
	DEPEND Aalpha_n, Kalpha_n, V0alpha_n, 
               Abeta_n, Kbeta_n, V0beta_n, celsius FROM -100 TO 30 WITH 13000 
	a_n = alp_n(v)  
	b_n = bet_n(v) 
	tau_n = 1/(a_n + b_n) 
	n_inf = a_n/(a_n + b_n) 
} 

FUNCTION linoid(x (mV),y (mV)) (mV) {
        if (fabs(x/y) < 1e-6) {
                linoid = y*(1 - x/y/2)
        }else{
                linoid = x/(exp(x/y) - 1)
        }
}

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