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Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)
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" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
Lombardo J, Harrington MA (2016) Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels.
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Neuron or other electrically excitable cell;
Spinal cord lumbar motor neuron alpha ACh cell;
Axonal Action Potentials;
Lombardo, Joseph [josslomb at gmail.com];
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Spinal cord lumbar motor neuron alpha ACh cell
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