Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)

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Accession:217882
" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
Reference:
1 . Lombardo J, Harrington MA (2016) Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels. J Neurophysiol 116:2114-2124 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Spinal motoneuron;
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Potassium; I K; I Na,t; I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials;
Implementer(s): Lombardo, Joseph [josslomb at gmail.com];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,t; I K; I M; I Potassium;
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LombardoHarrington2016
readme.html
Gfluctdv.mod *
ghchan.mod *
kca2.mod *
kdrRL.mod *
Km.mod *
kv1_gp.mod
L_Ca.mod *
mAHP.mod *
na3n.mod
na3rp.mod *
naps.mod *
napsi.mod *
buttons.png
ctrl.png
FR3cablepas.hoc
FRMot3dendNaHH.hoc
gKm0.png
GraphicsKmModulators.hoc
ModifiedFRMotoneuron.hoc
mosinit.hoc
retigabine.png
standard_0.hoc
Tools.ses
XE991.png
                            
// FRMotoneuronAdapted.hoc

access soma
insert Km  
insert kv1_gp

access axonhillock
insert Km 
insert kv1_gp

access is
insert Km 
insert kv1_gp

access soma

soma.diam = soma.diam/2
soma.L = soma.L/2
soma.g_pas = 0.00125*1.25
soma.e_pas = soma.e_pas+12
soma.gbar_kv1_gp = 0.01
soma.gbar_Km = 0.03

is.L = is.L/2.5
is.diam = is.diam/7
is.g_pas = 0.001*1.25
is.e_pas = is.e_pas+12
is.gbar_kv1_gp = 0.01
is.gbar_Km = 0.03

axonhillock.diam(0:1) = (4.5327/7):(13.32433/7)
axonhillock.g_pas = 0.001*1.25
axonhillock.e_pas = axonhillock.e_pas+12
axonhillock.gbar_kv1_gp = 0.01
axonhillock.gbar_Km = 0.03

forsec dend{
L = 4021.333/5
diam(0:0.2) = (16.827/7):(17.788/7)
diam(0.2:1) = (17.788/7):0.0
g_pas = 5e-05*1.25
e_pas = e_pas+12
}

forall if(ismembrane("mAHP")) gkcamax_mAHP=gkcamax_mAHP/3
forall if(ismembrane("na3rp")) sh_na3rp=sh_na3rp-1.75
forall if(ismembrane("naps")) sh_naps=sh_naps-1.75

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