Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)

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Accession:217882
" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
Reference:
1 . Lombardo J, Harrington MA (2016) Non-reciprocal mechanisms of up- and down-regulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels. J Neurophysiol :jn.00446.2016 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Spinal motoneuron;
Cell Type(s): Spinal cord lumbar motor neuron alpha cell;
Channel(s): I Potassium; I K; I Na,t; I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials;
Implementer(s): Lombardo, Joseph [josslomb at gmail.com];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha cell; I Na,t; I K; I M; I Potassium;
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LombardoHarrington2016
readme.html
Gfluctdv.mod *
ghchan.mod *
kca2.mod *
kdrRL.mod *
Km.mod *
kv1_gp.mod
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mAHP.mod *
na3n.mod
na3rp.mod *
naps.mod *
napsi.mod *
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FR3cablepas.hoc
FRMot3dendNaHH.hoc
gKm0.png
GraphicsKmModulators.hoc
ModifiedFRMotoneuron.hoc
mosinit.hoc
retigabine.png
standard_0.hoc
Tools.ses
XE991.png
                            
TITLE gh channel channel
: Hodgkin - Huxley h channel


NEURON {
	SUFFIX gh
	USEION k READ ek WRITE ik
	USEION na READ ena WRITE ina
	RANGE ghbar, ik, ina,htau, half, slp,inf
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v (mV)
	ghbar =.001 (mho/cm2) <0,1e9>
	htau = 50 (ms)
	half=-80 (mV)
	slp=8 (mV)
	ek = -77 (mV)
	ena = 50 (mV)
}
STATE {
	n
}
ASSIGNED {
	ik (mA/cm2)
	ina (mA/cm2)
	inf
}

INITIAL {
	rate(v)
	n = inf
}

BREAKPOINT {
	SOLVE states METHOD derivimplicit
	ik = 0.7*ghbar*n*(v - ek)
	ina = 0.3*ghbar*n*(v - ena)
}

DERIVATIVE states {	
	rate(v)
	n' = (inf - n)/htau
}
UNITSOFF

PROCEDURE rate(v(mV)) {	
	TABLE inf DEPEND half,slp FROM -100 TO 100 WITH 200
		inf = 1/(1+exp((v-half)/slp))
}
UNITSON

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