Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)

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Accession:217882
" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
Reference:
1 . Lombardo J, Harrington MA (2016) Non-reciprocal mechanisms of up- and down-regulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels. J Neurophysiol :jn.00446.2016 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Spinal motoneuron;
Cell Type(s): Spinal cord lumbar motor neuron alpha cell;
Channel(s): I Potassium; I K; I Na,t; I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials;
Implementer(s): Lombardo, Joseph [josslomb at gmail.com];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha cell; I Na,t; I K; I M; I Potassium;
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LombardoHarrington2016
readme.html
Gfluctdv.mod *
ghchan.mod *
kca2.mod *
kdrRL.mod *
Km.mod *
kv1_gp.mod
L_Ca.mod *
mAHP.mod *
na3n.mod
na3rp.mod *
naps.mod *
napsi.mod *
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ctrl.png
FR3cablepas.hoc
FRMot3dendNaHH.hoc
gKm0.png
GraphicsKmModulators.hoc
ModifiedFRMotoneuron.hoc
mosinit.hoc
retigabine.png
standard_0.hoc
Tools.ses
XE991.png
                            
TITLE Potassium Delayed Rectifier Channel
	:This channel is a Voltage Dependent Potassium Channel
	: and will create a current (ik) based on the voltage 
	:Simplied by RKP 3/22/07 to exlude references to different
	: parts of Bob's split dendrite model

UNITS {
	(mV) = (millivolt)
	(mA) = (milliamp)
	(S) = (siemens)
}

NEURON {
	SUFFIX kdrRL
	USEION k READ ek WRITE ik
	RANGE ik, g, gMax
	GLOBAL  mVh,mslp, tVh, tslp, tmin,taumax
}

PARAMETER {
	gMax = 0.1 (S/cm2)
	mVh = -25 (mV)
	mslp = 20 (mV)
	tVh = -39 (mV)			
	tslp = 5.5 (mV)			
	tmin = 1.4 (ms)		
	taumax = 11.9(ms)
}			

ASSIGNED {
	v   (mV)
	ek  (mV)
	ik  (mA/cm2)
	g   (S/cm2)
	mtau (ms)
	minf
}

STATE {
	m
}

INITIAL {
	rate(v)
	m = minf
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	g = gMax * m^4
	ik = g*(v - ek)
}

DERIVATIVE state {
	rate(v)
	m' = (minf - m)/mtau
}

PROCEDURE rate(v (mV)) {
	LOCAL b, f TABLE minf,mtau 
	DEPEND mVh,mslp,tVh,tslp,tmin,taumax 
	FROM -100 TO 100 WITH 200

	b = exp((v - tVh)/tslp)
	f = (1 + b)^2
	
	minf = 1/(1+exp(-(v-mVh)/mslp))
	mtau = tmin + taumax*b/f
}

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