Parallel cortical inhibition processing enables context-dependent behavior (Kuchibhotla et al. 2016)

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Accession:217958
Physical features of sensory stimuli are fixed, but sensory perception is context dependent. The precise mechanisms that govern contextual modulation remain unknown. Here, we trained mice to switch between two contexts: passively listening to pure tones and performing a recognition task for the same stimuli. Two-photon imaging showed that many excitatory neurons in auditory cortex were suppressed during behavior, while some cells became more active. Whole-cell recordings showed that excitatory inputs were affected only modestly by context, but inhibition was more sensitive, with PV+, SOM+, and VIP+ interneurons balancing inhibition and disinhibition within the network. Cholinergic modulation was involved in context switching, with cholinergic axons increasing activity during behavior and directly depolarizing inhibitory cells. Network modeling captured these findings, but only when modulation coincidently drove all three interneuron subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagement. Parallel processing of cholinergic modulation by cortical interneurons therefore enables context-dependent behavior.
Reference:
1 . Kuchibhotla KV, Gill JV, Lindsay GW, Papadoyannis ES, Field RE, Sten TA, Miller KD, Froemke R (2016) Parallel processing by cortical inhibition enables context-dependent behavior. Nat Neurosci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Connectionist Network;
Brain Region(s)/Organism: Auditory cortex;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: MATLAB;
Model Concept(s): Rate-coding model neurons; Sensory processing;
Implementer(s): Lindsay, Grace ; Miller, Kenneth ;
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