Changes of ionic concentrations during seizure transitions (Gentiletti et al. 2016)

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Accession:222321
"... In order to investigate the respective roles of synaptic interactions and nonsynaptic mechanisms in seizure transitions, we developed a computational model of hippocampal cells, involving the extracellular space, realistic dynamics of Na+, K+, Ca2+ and Cl - ions, glial uptake and extracellular diffusion mechanisms. We show that the network behavior with fixed ionic concentrations may be quite different from the neurons’ behavior when more detailed modeling of ionic dynamics is included. In particular, we show that in the extended model strong discharge of inhibitory interneurons may result in long lasting accumulation of extracellular K+, which sustains the depolarization of the principal cells and causes their pathological discharges. ..."
Reference:
1 . Gentiletti D, Suffczynski P, Gnatkovsky V, de Curtis M (2017) Changes of Ionic Concentrations During Seizure Transitions - A Modeling Study. Int J Neural Syst 27:1750004 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Extracellular; Realistic Network;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s):
Channel(s): Na/K pump; KCC2; I Na, leak; I K,leak; I Na,t; I Na,p; I K; I L high threshold; I_AHP; I M; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Ions;
Simulation Environment: NEURON;
Model Concept(s): Epilepsy; Reaction-diffusion; Synchronization; Simplified Models;
Implementer(s): Gentiletti, Damiano [gentiletti.damiano at gmail.com];
Search NeuronDB for information about:  I Na,p; I Na,t; I L high threshold; I K; I K,leak; I M; I K,Ca; Na/K pump; I_AHP; I Na, leak; KCC2; Ions;
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GentilettiEtAl2016
readme.html
accum.mod
cal.mod
getconc.mod
ikdrd.mod
ikdrs.mod
inad.mod
inas.mod
is.mod
kahp.mod
kc.mod
kcc2.mod
km.mod
leak.mod
LinClamp.mod
nakpump.mod
nap.mod
pkdrd.mod
pkdrs.mod
pnad.mod
pnas.mod
init.hoc
mosinit.hoc *
MySession.ses
screenshot.png
                            
NEURON {
	SUFFIX getconc
	USEION na WRITE nai, nao
	USEION  k WRITE  ki,  ko
	USEION ca WRITE cai, cao
	USEION cl WRITE cli, clo
	POINTER naip, naop, kip, kop, caip, caop, clip, clop
}

ASSIGNED {
	naip naop kip kop caip caop clip clop
}

STATE { nai nao ki ko cai cao cli clo }

BREAKPOINT {
	  nai=naip nao=naop
	  ki=kip   ko=kop
	  cai=caip cao=caop
          cli=clip clo=clop
}

INITIAL {
	at_time(t) {
	  nai=naip nao=naop
          ki=kip   ko=kop
	  cai=caip cao=caop
	  cli=clip clo=clop
	}
}

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