Synaptic integration by MEC neurons (Justus et al. 2017)

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Accession:222359
Pyramidal cells, stellate cells and fast-spiking interneurons receive running speed dependent glutamatergic input from septo-entorhinal projections. These models simulate the integration of this input by the different MEC celltypes.
Reference:
1 . Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S (2017) Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nat Neurosci 20:16-19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s): Entorhinal cortex pyramidal cell; Entorhinal cortex stellate cell; Entorhinal cortex fast-spiking interneuron;
Channel(s): I K; I Na,t; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration; Simplified Models;
Implementer(s): Justus, Daniel [daniel.justus at dzne.de];
Search NeuronDB for information about:  AMPA; I Na,t; I K; I h; Glutamate;
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NEURON_mEC
data
README.html
exp2syn_depress.mod
h.mod *
kap.mod *
kdr.mod *
nax.mod
vecevent.mod *
cinit.hoc
EPSPparam.hoc
GUI.hoc
GUIfunctions.hoc
init.hoc
insert_noise_Syn.hoc
insert_real_Syn.hoc
insertsyn.hoc
morphology.hoc
mosinit.hoc *
Parameters.hoc
run_real_input.hoc
screenshot1.png
screenshot2.png
screenshot3.png
Voltage.ses
                            
strdef ICString,InputString

proc ControlPanel(){
	SynBackground=8
	SynSpeed=0
	
	ICString = "0 pA"
	InputString = "0 %"
	x=1
	xpanel("MEC neuron",0)
		//Celltype selection
		xradiobutton("Pyramidal Cell","Parameters_PYR()",1)
		xradiobutton("Stellate Cell","Parameters_STELLATE()")
		xradiobutton("Fast-spiking interneuron","Parameters_IN()")
				
		xlabel("")
		
		//Step current injection
		xlabel("Step current injection")
		xslider(&IC.amp, -.5, .5, "sprint(ICString, \"%g pA\", IC.amp*1000)")
		xvarlabel(ICString)
		xbutton("Step current","currentInj_loc()")
		xlabel("")
		
		//Synaptic input
		xlabel("Synaptic input")
		xbutton("Single EPSP","singleEPSP_loc()")
		xbutton("Repeated EPSP","repeatedEPSP_loc()")
		xlabel("")
		xlabel("")
		
		//Realistic input
		
		xlabel("Realistic synaptic input")
		xlabel("Strength of speed-tuned input")
		xslider(&SynSpeed, 0, 150, "sprint(InputString, \"%g %\", SynSpeed)")
		xvarlabel(InputString)
		xlabel("")
		xbutton("Unit 2","run_real_input_loc(SynBackground,SynBackground*SynSpeed/100,250000,\"unit2.dat\")")
		xbutton("Unit 3","run_real_input_loc(SynBackground,SynBackground*SynSpeed/100,250000,\"unit3.dat\")")
		xlabel("")
		xbutton("Supplementary Unit 1","run_real_input_loc(SynBackground,SynBackground*SynSpeed/100,1500000,\"supplementaryUnit1.dat\")")
		xbutton("Supplementary Unit 2","run_real_input_loc(SynBackground,SynBackground*SynSpeed/100,1500000,\"supplementaryUnit2.dat\")")
		xlabel("")
		xbutton("Random Unit 1","run_real_input_loc(SynBackground,SynBackground*SynSpeed/100,500000,\"randomUnit1.dat\")")
		xbutton("Random Unit 2","run_real_input_loc(SynBackground,SynBackground*SynSpeed/100,500000,\"randomUnit2.dat\")")
		
		xlabel("")
		xbutton("Stop","stopThisRun()")
	xpanel(0)
}

proc currentInj_loc(){
	stopThisRun()
	currentInj()
}

proc singleEPSP_loc(){
	stopThisRun()
	IC.amp=0
	ICString = "0 pA"
	singleEPSP()
}

proc repeatedEPSP_loc(){
	stopThisRun()
	IC.amp=0
	ICString = "0 pA"
	repeatedEPSP()
}

proc run_real_input_loc(){
	stopThisRun()
	IC.amp=0
	ICString = "0 pA"
	print $1
	print $2
	run_real_input($1,$2,$3,$s4)
	

	objref SynB[10000]
	objref SynR[10000]
}

proc stopThisRun(){
	stoprun=1
	weight=0
	insertsynE(sSec,0,200,1,1,0,200,1)
	
	objref SynB[10000]
	objref SynR[10000]
}

	



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