Synaptic integration by MEC neurons (Justus et al. 2017)

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Accession:222359
Pyramidal cells, stellate cells and fast-spiking interneurons receive running speed dependent glutamatergic input from septo-entorhinal projections. These models simulate the integration of this input by the different MEC celltypes.
Reference:
1 . Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S (2017) Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nat Neurosci 20:16-19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s): Entorhinal cortex pyramidal cell; Entorhinal cortex stellate cell; Entorhinal cortex fast-spiking interneuron;
Channel(s): I K; I Na,t; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration; Simplified Models;
Implementer(s): Justus, Daniel [daniel.justus at dzne.de];
Search NeuronDB for information about:  AMPA; I Na,t; I K; I h; Glutamate;
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NEURON_mEC
data
README.html
exp2syn_depress.mod
h.mod *
kap.mod *
kdr.mod *
nax.mod
vecevent.mod *
cinit.hoc
EPSPparam.hoc
GUI.hoc
GUIfunctions.hoc
init.hoc
insert_noise_Syn.hoc
insert_real_Syn.hoc
insertsyn.hoc
morphology.hoc
mosinit.hoc *
Parameters.hoc
run_real_input.hoc
screenshot1.png
screenshot2.png
screenshot3.png
Voltage.ses
                            
func singleEPSP(){													// generates a single glutamatergic EPSP
	tau1=.01
	tau2=45
	weight=9e-4
	
	tstop=700
	Graph[0].size(0,tstop,-80,-50)
	EPSPparam(tau1,tau2,weight)
	weight=0
	insertsynE(sSec,0,200,1,1,0,200,1)
	return 1
}

func repeatedEPSP(){												// generates glutamatergic EPSPs at 3 to 12 Hz
																	// and calculates mean amplitude and first-to-last amplitude ratio
	tau1=.01
	tau2=45
	weight=9e-4

	tstop=1500
	Graph[0].size(0,tstop,-80,-50)
	stoprun=0
	runInd=1
	while(stoprun==0 && runInd<=4){
		print "\n",3*runInd,"Hz"
		EPSPStim(tau1,tau2,weight,1000,3*runInd)
		runInd+=1
	}
	
	weight=0
	insertsynE(sSec,0,200,1,1,0,200,1)
	return 1
}

func currentInj(){													// performs a somatic step-current injection with an amplitude given by the slider
	IC.del=200
	IC.dur=500
	tstop=1000
	Graph[0].size(0,tstop,-100,40)
	cinit()
	run()
	return 1
}
		

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