Synaptic integration by MEC neurons (Justus et al. 2017)

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Accession:222359
Pyramidal cells, stellate cells and fast-spiking interneurons receive running speed dependent glutamatergic input from septo-entorhinal projections. These models simulate the integration of this input by the different MEC celltypes.
Reference:
1 . Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S (2017) Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nat Neurosci 20:16-19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s): Entorhinal cortex pyramidal cell; Entorhinal cortex stellate cell; Entorhinal cortex fast-spiking interneuron;
Channel(s): I K; I Na,t; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration; Simplified Models;
Implementer(s): Justus, Daniel [daniel.justus at dzne.de];
Search NeuronDB for information about:  AMPA; I Na,t; I K; I h; Glutamate;
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NEURON_mEC
data
README.html
exp2syn_depress.mod
h.mod *
kap.mod *
kdr.mod *
nax.mod
vecevent.mod *
cinit.hoc
EPSPparam.hoc
GUI.hoc
GUIfunctions.hoc
init.hoc
insert_noise_Syn.hoc
insert_real_Syn.hoc
insertsyn.hoc
morphology.hoc
mosinit.hoc *
Parameters.hoc
run_real_input.hoc
screenshot1.png
screenshot2.png
screenshot3.png
Voltage.ses
                            
strdef celltype

proc Parameters_PYR(){

	celltype="Pyramidal cell"

	Ra_global=150				/* internal resistivity in (ohm/cm) */
	
	cm_global=8.044 			/* specific membrane capacitance (uF/cm^2) */
	Rm=5497.129					/* specific membrane resistivity (ohm*cm^2) */ 

	gpas=1/Rm					/* passive conductance*/
	eleak=-72
	ghcn=4.47798e-5
	
	gnabar=0.025*(1.05^30)		/* sodium conductance (S/cm^2) ~0,1798 */
	gkbar=0.025*(1.05^39)		/* potassium conductance ~1,4305 */
	gkdr=0.025*(1.05^54)		/* inward rectifying potassium conductance ~1,0637 */

	celsius=35
	
	setParameters()
}


proc Parameters_STELLATE(){

	celltype="Stellate cell"

	Ra_global=150				/* internal resistivity in (ohm/cm) */
	cm_global=8.86977			/* specific membrane capacitance (uF/cm^2) */
	Rm=3178.63					/* specific membrane resistivity (ohm*cm^2) */  

	gpas=1/Rm					/* passive conductance*/
	eleak=-68
	
	ghcn=3.2327e-4

	gnabar=0.025*(1.05^45)		/* sodium conductance (S/cm^2) ~0,1798 */
	gkbar=0.025*(1.05^55)		/* potassium conductance ~1,4305 */
	gkdr=0.025*(1.05^44)		/* inward rectifying potassium conductance ~1,0637 */

	celsius=35
	
	setParameters()
}


proc Parameters_IN(){

	celltype="Fast-spiking interneuron"

	Ra_global=150				/* internal resistivity in (ohm/cm) */
	cm_global=3.0346			/* specific membrane capacitance (uF/cm^2) */
	Rm=7528.7606				/* specific membrane resistivity (ohm*cm^2) */  

	gpas=1/Rm					/* passive conductance*/
	eleak=-78

	gnabar=0.025*(1.05^18)		/* sodium conductance (S/cm^2) ~0,1798 */
	gkbar=0.025*(1.05^55)		/* potassium conductance ~1,4305 */
	gkdr=0.025*(1.05^49)		/* inward rectifying potassium conductance ~1,0637 */
	
	ghcn=2.0369e-5

	celsius=35
	
	setParameters()
}

proc Parameters_otherIN(){

	celltype="regular spiking interneuron"

	Ra_global=150				/* internal resistivity in (ohm/cm) */
	cm_global=3.202				/* specific membrane capacitance (uF/cm^2) */
	Rm=11745.033				/* specific membrane resistivity (ohm*cm^2) */  

	gpas=1/Rm					/* passive conductance*/
	eleak=-71.0567

	gnabar=.08					/* sodium conductance (S/cm^2) */
	gkbar=.06					/* potassium conductance */
	gkdr=.2						/* inward rectifying potassium conductance */
	ghcn=3.3181e-5

	celsius=35
	
	setParameters()
}


proc setParameters(){
	
	soma{
		gbar_nax=gnabar
		gkabar_kap=gkbar
		gkdrbar_kdr=gkdr
	
		ghdbar_hd=ghcn
		g_pas=gpas 
		cm=cm_global
	}
	
	dend{
		gbar_nax=0
		gkabar_kap=0
		gkdrbar_kdr=0
	
		ghdbar_hd=ghcn
		g_pas=gpas 
		cm=cm_global
	}
	
	forall{
		e_pas=eleak Ra=Ra_global 
	}
	print celltype
	
	cinit()
}
		
	

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