Synaptic integration by MEC neurons (Justus et al. 2017)

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Accession:222359
Pyramidal cells, stellate cells and fast-spiking interneurons receive running speed dependent glutamatergic input from septo-entorhinal projections. These models simulate the integration of this input by the different MEC celltypes.
Reference:
1 . Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S (2017) Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nat Neurosci 20:16-19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s): Entorhinal cortex pyramidal cell; Entorhinal cortex stellate cell; Entorhinal cortex fast-spiking interneuron;
Channel(s): I K; I Na,t; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration; Simplified Models;
Implementer(s): Justus, Daniel [daniel.justus at dzne.de];
Search NeuronDB for information about:  AMPA; I Na,t; I K; I h; Glutamate;
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NEURON_mEC
data
README.html
exp2syn_depress.mod
h.mod *
kap.mod *
kdr.mod *
nax.mod
vecevent.mod *
cinit.hoc
EPSPparam.hoc
GUI.hoc
GUIfunctions.hoc
init.hoc
insert_noise_Syn.hoc
insert_real_Syn.hoc
insertsyn.hoc
morphology.hoc
mosinit.hoc *
Parameters.hoc
run_real_input.hoc
screenshot1.png
screenshot2.png
screenshot3.png
Voltage.ses
                            
load_file("nrngui.hoc")

objref sSec,dendSec,axonSec,sdSec,IC
objref vSamp,dvSamp,dfile
objref ICsteady									// for correcting Baseline potential during fitting

objref SynE[10000]
objref SynI[10000]
objref NCE[10000]
objref NCI[10000]
objref NetSE[10000]
objref NetSI[10000]

xopen("cinit.hoc")
xopen("morphology.hoc")
xopen("Parameters.hoc")

sSec=new SectionList()
dendSec=new SectionList()
axonSec=new SectionList()
sdSec=new SectionList()

vSamp=new Vector()
dvSamp=new Vector()
dfile=new File()

soma sSec.append()
dend dendSec.append()

soma sdSec.append()
dend sdSec.append()

forsec sdSec{
	insert nax
	insert kap
	insert kdr
	insert hd
}

forall{
	insert pas
}

soma{
	IC=new IClamp(.5)
	ICsteady=new IClamp(.5)
}

proc longIC(){
	IC.amp=0.5
	IC.dur=500
	IC.del=100
	tstop=700
}

proc shortIC(){
	IC.amp=.8
	IC.dur=3
	IC.del=0
	tstop=10
}

ICsteady.del=-1e4
ICsteady.dur=2e4
ICsteady.amp=0

Parameters_PYR()

tstop=700

proc init() {
	finitialize()
	tSTOP=tstop
	t=0
	tstop=tSTOP
}


xopen("EPSPparam.hoc")
xopen("insert_real_Syn.hoc")
xopen("insert_noise_Syn.hoc")

xopen("run_real_input.hoc")
xopen("GUIfunctions.hoc")

xopen("GUI.hoc")
ControlPanel()

xopen("voltage.ses")

cinit()



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