Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)

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Accession:223649
" ... We hypothesized that currents are grouped into distinct modules that shape specific neuronal characteristics or signatures, such as resting potential, sub-threshold oscillations, and spiking waveforms, for several classes of neurons. For such a grouping to occur, the currents within one module should have minimal functional interference with currents belonging to other modules. This condition is satisfied if the gating functions of currents in the same module are grouped together on the voltage axis; in contrast, such functions are segregated along the voltage axis for currents belonging to different modules. We tested this hypothesis using four published example case models and found it to be valid for these classes of neurons. ..."
Reference:
1 . Alturki A, Feng F, Nair A, Guntu V, Nair SS (2016) Distinct current modules shape cellular dynamics in model neurons. Neuroscience 334:309-331 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Amygdala;
Cell Type(s): Abstract single compartment conductance based cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Activity Patterns; Oscillations; Methods; Olfaction;
Implementer(s):
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AlturkiEtAl2016
2_Pospischil
Original
Segregated
readme_Pospischil_et_al_2008.txt
                            
This is to replicate Fig.A3A in Alturki et al., 2016

AFTER YOU COMPILE THE FILES (see below):

ORIGINAL
To run the original model of Pospischil et al:
1- Click on mosinit.hoc, several windows will automatically pop up
2- Select IClamp from the "I/V Clamp Electrode" window
3- Select the cell type from the list in the "Simulations of cortical cells" window, we studied 4 cell types:
	- RS cell (the 1st one in the list)
	- Bursting (2nd in the list)
	- Low Threshold Spiking LTS (4th in the list)
	- FS (5th in the list)
4- After selecting the cell type, click on Init & Run fom the "RunControl" window

SEGREGATED
To run the segregated model of Pospischil et al:
1- Click on mosinit.hoc, several windows will automatically pop up
2- Select IClamp from the "I/V Clamp Electrode" window
3- Select the cell type from the list in the "Simulations of cortical cells" window.We studied 4 cell types:
	- RS cell (the 1st one in the list)
	- Bursting (2nd in the list)
	- Low Threshold Spiking LTS (4th in the list)
	- FS (5th in the list)
4- After selecting the cell type, click on Init & Run fom the "RunControl" window

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TO COMPILE AND RUN THE MODEL IN THE FOLDERS 'ORIGINAL' OR 'SEGREGATED' DO THE FOLLOWING:

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui FILENAME.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
FILENAME.hoc 
will open the simulation window.

Under MAC OS X:
Drag and drop the FILE folder onto the mknrndll icon in the NEURON
application folder. When the mod files are finished compiling, double click on the simulation file FILENAME.hoc

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