Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)

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Accession:223649
" ... We hypothesized that currents are grouped into distinct modules that shape specific neuronal characteristics or signatures, such as resting potential, sub-threshold oscillations, and spiking waveforms, for several classes of neurons. For such a grouping to occur, the currents within one module should have minimal functional interference with currents belonging to other modules. This condition is satisfied if the gating functions of currents in the same module are grouped together on the voltage axis; in contrast, such functions are segregated along the voltage axis for currents belonging to different modules. We tested this hypothesis using four published example case models and found it to be valid for these classes of neurons. ..."
Reference:
1 . Alturki A, Feng F, Nair A, Guntu V, Nair SS (2016) Distinct current modules shape cellular dynamics in model neurons. Neuroscience 334:309-331 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Amygdala;
Cell Type(s): Abstract single compartment conductance based cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Activity Patterns; Oscillations; Methods; Olfaction;
Implementer(s):
/
AlturkiEtAl2016
3_Mitral
Original
readme.txt *
cadecay.mod *
Ih.mod *
INaP.mod
kA.mod
kca3.mod
kfasttab.mod *
kO.mod *
kslowtab.mod *
lcafixed.mod *
nafast.mod
kfast_k.inf *
kfast_k.tau *
kfast_k.txt *
kfast_n.inf *
kfast_n.tau *
kfast_n.txt *
kslow_k.inf *
kslow_k.tau *
kslow_k.txt *
kslow_n.inf *
kslow_n.tau *
kslow_n.txt *
mitral.hoc
mosinit.hoc *
tabchannels.hoc *
                            
Mitral cell model for dynamical olfactory bulb networks

From:
 	Rubin D, Cleland TA (2006) 
	Dynamical mechanisms of odor processing in olfactory bulb 
	mitral cells.  
	J Neurophysiology.

This model mitral cell (the principal output neuron of the vertebrate 
olfactory bulb) comprises four compartments (soma, apical dendrite, 
apical tuft, lateral dendrite) and exhibits endogenous subthreshold 
oscillations, phase resetting, and evoked spike phasing properties 
as described in mitral cells by:

  (1) Desmaisons D, Vincent JD, Lledo PM (1999) 
	Control of action potential timing by intrinsic subthreshold 
	oscillations in olfactory bulb output neurons.  
	J Neuroscience 29(24):10727-10737.
  (2) Balu R, Larimer P, Strowbridge BW (2004)
	Phasic stimuli evoke precisely timed spikes in intermittently 
	discharging mitral cells.
	J Neurophysiology 92(2):743-753.
  (3) Chen WR, Shepherd GM (1997) 
	Membrane and synaptic properties of mitral cells in slices of 
	rat olfactory bulb.
	Brain Research 745(1-2):189-196.
  (4) Heyward P, Ennis M, Keller A, Shipley MT (2001) 
	Membrane bistability in olfactory bulb mitral cells.
	J Neuroscience 21(14):5311-5320.
	
Adapted from the model of:
	Davison AP, Feng J and Brown D. (2000) A reduced compartmental model 
	of the mitral cell for use in network models of the olfactory bulb.
      Brain Research Bulletin 51(5): 393-399.

Run the model using the file mosinit.hoc after compiling the .mod files.

An xpanel will appear enabling easy recreation of many figures from the 
2006 paper.  Be patient on slower machines as traces will by default only 
become visible after 1600-2000 ms computed time.  Parameters can be derived 
from the xpanel code or from the tables in the 2006 paper.  

For more information contact Thomas Cleland (tac29@cornell.edu).


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