Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)

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Accession:223649
" ... We hypothesized that currents are grouped into distinct modules that shape specific neuronal characteristics or signatures, such as resting potential, sub-threshold oscillations, and spiking waveforms, for several classes of neurons. For such a grouping to occur, the currents within one module should have minimal functional interference with currents belonging to other modules. This condition is satisfied if the gating functions of currents in the same module are grouped together on the voltage axis; in contrast, such functions are segregated along the voltage axis for currents belonging to different modules. We tested this hypothesis using four published example case models and found it to be valid for these classes of neurons. ..."
Reference:
1 . Alturki A, Feng F, Nair A, Guntu V, Nair SS (2016) Distinct current modules shape cellular dynamics in model neurons. Neuroscience 334:309-331 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Amygdala;
Cell Type(s): Abstract single compartment conductance based cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Activity Patterns; Oscillations; Methods; Olfaction;
Implementer(s):
/
AlturkiEtAl2016
3_Mitral
Segregated
cadecay.mod *
Ih.mod
INaP.mod
kA.mod
kca3.mod
kfasttab.mod
kO.mod
kslowtab.mod
lcafixed.mod
nafast.mod
kfast_k.inf *
kfast_k.tau *
kfast_k.txt *
kfast_k_tau.txt *
kfast_n.inf *
kfast_n.tau *
kfast_n.txt *
kfast_n_tau.txt *
kslow_k.inf *
kslow_k.tau *
kslow_k.txt *
kslow_k_tau.txt *
kslow_n.inf *
kslow_n.tau *
kslow_n.txt *
kslow_n_tau.txt *
mitral.hoc
mosinit.hoc *
tabchannels.hoc *
                            
TITLE Calcium decay
: Implemented in Rubin and Cleland (2006) J Neurophysiology
: written by Andrew Davison et al (2000) Brain Res Bulletin
: as described in Bhalla and Bower (1993) J Neurophysiology 69:1948-1983 (1993)
: partially based on cadecay.mod by Alain Destexhe, Salk Institute 1995.

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms) }

NEURON{
	SUFFIX cad
	USEION ca READ ica, cai WRITE cai
	RANGE ica, channel_flow, depth, B
	GLOBAL cai, tau, cainf
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) = (millimolar)
	(um) = (micron)
}

CONSTANT {
      FARADAY = 96154 (coul)
	:FARADAY = 93149 (coul)		: moles do not appear in units
						: note this value is chosen to fit with
						: Genesis
}

PARAMETER {
	dt (ms)
	depth = 1 	(um)		: shell within which cai is calculated
					: to match Bhalla and Bower 1993 set
					: depth = diam/4 for each compartment
	tau = 1e-5 	(ms)		: cai decay constant
	cainf = 1e-5	(mM)		: baseline calcium concentration
	ica		(mA/cm2)
}

STATE {
	cai		(mM)
}

INITIAL {
	cai = cainf
}

ASSIGNED {
	channel_flow	(mM/ms)
	B		(mM cm2/ms/mA)
}

BREAKPOINT {
	SOLVE state METHOD cnexp
}

DERIVATIVE state {
	B = -(1e4)/(2*FARADAY*depth)
	channel_flow = B*ica
	if (channel_flow <= 0.0 ) { channel_flow = 0.0 }	: one way flow in channel
	cai' = channel_flow  - (cai - cainf)/tau
}
	






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