Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)

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Accession:223891
" ... Here, combining data from fluorescence-targeted dendritic recordings and Ca2+ imaging from low-threshold spiking cells in rat brain slices with computational modeling, the cellular mechanism responsible for LTS (Low Threshold Spike) generation is established. ..." " ... Using dendritic recording, 2-photon glutamate uncaging, and computational modeling, we investigated how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothalamic feedback. ..."
References:
1 . Connelly WM, Crunelli V, Errington AC (2016) Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites. J Neurosci 36:3735-54 [PubMed]
2 . Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I T low threshold; I Calcium; I h;
Gap Junctions:
Receptor(s): NMDA; AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Active Dendrites; Action Potential Initiation; Calcium dynamics;
Implementer(s): Connelly, William [connelly.bill at gmail.com];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; AMPA; NMDA; I T low threshold; I h; I Calcium; Glutamate;
COMMENT
Chirp/Swept Sine/Zap function as a pointprocess. 
Code amalgamated from the Neuron board
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=8&t=897
Thanks to Ted and users kelvin and crutchley.
ENDCOMMENT

NEURON {
  POINT_PROCESS Izap
  RANGE del, dur, f0, f1, amp, i
  ELECTRODE_CURRENT i
}

UNITS {
  (nA) = (nanoamp)
  PI = (pi) (1)
}

PARAMETER {
  del (ms)
  dur (ms)
  f0 (1/s)  : frequency is in Hz
  f1 (1/s)
  amp (nA)
}

ASSIGNED {
  f (1/s)
  i (nA)
}

INITIAL {
  i = 0

  if (del<0) { del=0 }
  if (dur<0) { dur=0 }
  if (f0<=0) { f0=0 (1/s) }
  if (f1<=0) { f1=0 (1/s) }

}


BREAKPOINT {
  at_time(del)
  at_time(del + dur)

  if (t < del) {
    i=0   
  } else { 
    if (t < del+dur) {
      i = amp*sin(2*PI * (t - del) * (f0 + (f1 - f0)*(t-del)/(2*dur)) * 0.001)
    } else { 
      i = 0
    }
  }
}

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