Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)

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Accession:223891
" ... Here, combining data from fluorescence-targeted dendritic recordings and Ca2+ imaging from low-threshold spiking cells in rat brain slices with computational modeling, the cellular mechanism responsible for LTS (Low Threshold Spike) generation is established. ..." " ... Using dendritic recording, 2-photon glutamate uncaging, and computational modeling, we investigated how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothalamic feedback. ..."
References:
1 . Connelly WM, Crunelli V, Errington AC (2016) Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites. J Neurosci 36:3735-54 [PubMed]
2 . Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I T low threshold; I Calcium; I h;
Gap Junctions:
Receptor(s): NMDA; AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Active Dendrites; Action Potential Initiation; Calcium dynamics;
Implementer(s): Connelly, William [connelly.bill at gmail.com];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; AMPA; NMDA; I T low threshold; I h; I Calcium; Glutamate;
TITLE I-h channel for Thalamic neurons from McCormick and Pape (1990)

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
        v 		(mV)
        eh  		(mV)        
        celsius 	(degC)
        ghbar=.00005 	(mho/cm2)
        vhalft=-80   	(mV)
        a0t=0.0005      	(/ms)
        zetat=0.2    	(1)
        gmt=.65   	(1)
        q10=4.5
        shift=0   (mV)
}


NEURON {
        SUFFIX htc
        NONSPECIFIC_CURRENT i
        RANGE ghbar, eh
	THREADSAFE
        GLOBAL linf,taul,shift
}

STATE {
        l
}

ASSIGNED {
        i (mA/cm2)
        linf      
        taul
}

INITIAL {
	rate(v)
	l=linf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	i = ghbar*l*(v-eh)

}


FUNCTION alpt(v(mV)) {
  alpt = exp(zetat*(v-vhalft+shift)) 
}

FUNCTION bett(v(mV)) {
  bett = exp(zetat*gmt*(v-vhalft+shift)) 
}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rate(v)
        l' =  (linf - l)/taul
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL qt
        qt=q10^((celsius-36)/10)
        linf = 1/(1+ exp((v+75+shift)/5.5))
        taul = bett(v)/(qt*a0t*(1+alpt(v)))
}

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