Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)

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Accession:223891
" ... Here, combining data from fluorescence-targeted dendritic recordings and Ca2+ imaging from low-threshold spiking cells in rat brain slices with computational modeling, the cellular mechanism responsible for LTS (Low Threshold Spike) generation is established. ..." " ... Using dendritic recording, 2-photon glutamate uncaging, and computational modeling, we investigated how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothalamic feedback. ..."
References:
1 . Connelly WM, Crunelli V, Errington AC (2016) Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites. J Neurosci 36:3735-54 [PubMed]
2 . Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I T low threshold; I Calcium; I h;
Gap Junctions:
Receptor(s): NMDA; AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Active Dendrites; Action Potential Initiation; Calcium dynamics;
Implementer(s): Connelly, William [connelly.bill at gmail.com];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; AMPA; NMDA; I T low threshold; I h; I Calcium; Glutamate;
TITLE Inward Rectifying Potassium Channel (IRK)

COMMENT
	*********************************************
	reference:	NISENBAUM, E. S. & WILSON, C. J. (1995). Potassium currents
responsible for inward and outward rectification in rat neostriatal
spiny projection neurons. Journal of Neuroscience 15, 4449-4463. 	

as reported in Williams SR et al., J Physiol (1997)

William Connelly 2013
	*********************************************
  
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX irk
	USEION k READ ek WRITE ik 
  RANGE gkbar, m_inf, tau_m 
  GLOBAL shift
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v		(mV)
	ek		(mV)
	gkbar= 0.0005	(mho/cm2)
  tau_m = 1.0
  shift = 0
}

STATE {
	m
}

ASSIGNED {
	ik		(mA/cm2)
	m_inf
}

BREAKPOINT { 
	SOLVE states METHOD cnexp
 	ik = gkbar * m^3 * (v-ek)
}

DERIVATIVE states { 
	evaluate_fct(v)
	m'= (m_inf-m) / tau_m
}

INITIAL {
	evaluate_fct(v)
	m = m_inf
}

PROCEDURE evaluate_fct(v(mV)) {

	m_inf = 1/(1 + exp( (v - ek - 15 + shift)/10) )
}


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