Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)

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Accession:223891
" ... Here, combining data from fluorescence-targeted dendritic recordings and Ca2+ imaging from low-threshold spiking cells in rat brain slices with computational modeling, the cellular mechanism responsible for LTS (Low Threshold Spike) generation is established. ..." " ... Using dendritic recording, 2-photon glutamate uncaging, and computational modeling, we investigated how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothalamic feedback. ..."
References:
1 . Connelly WM, Crunelli V, Errington AC (2016) Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites. J Neurosci 36:3735-54 [PubMed]
2 . Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I T low threshold; I Calcium; I h;
Gap Junctions:
Receptor(s): NMDA; AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Active Dendrites; Action Potential Initiation; Calcium dynamics;
Implementer(s): Connelly, William [connelly.bill at gmail.com];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; AMPA; NMDA; I T low threshold; I h; I Calcium; Glutamate;
NEURON {
	POINT_PROCESS isyn
	RANGE del, amp, tau1, tau2, i, factor
	ELECTRODE_CURRENT i
}
UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
}

PARAMETER {
	del=0 (ms)
	tau1=.5 (ms)	<1e-3,1e6>
	tau2=1 (ms)   <1e-3,1e6>
	amp=0 	(nA)	<0,1e9>
	factor
}

ASSIGNED {
  v (mV)
  i (nA) 
}

INITIAL {
  if (tau1==tau2) {
    tau1 = tau1*0.999
  }
  factor = -1*((tau2/tau1)^(tau2/(tau1-tau2)))*((tau2-tau1)/tau1)
}

BREAKPOINT {
	if (amp) { at_time(del) }
	i = twoexp( (t - del) )
}

FUNCTION twoexp(x(ms)) (nA) {
  if (x < 0 || x/tau2 > 10) {
    twoexp = 0
  }else{
    twoexp = -amp/factor*(exp(-x/tau2)-exp(-x/tau1))
  }
}


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