Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)

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Accession:223891
" ... Here, combining data from fluorescence-targeted dendritic recordings and Ca2+ imaging from low-threshold spiking cells in rat brain slices with computational modeling, the cellular mechanism responsible for LTS (Low Threshold Spike) generation is established. ..." " ... Using dendritic recording, 2-photon glutamate uncaging, and computational modeling, we investigated how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothalamic feedback. ..."
References:
1 . Connelly WM, Crunelli V, Errington AC (2016) Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites. J Neurosci 36:3735-54 [PubMed]
2 . Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I T low threshold; I Calcium; I h;
Gap Junctions:
Receptor(s): NMDA; AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Active Dendrites; Action Potential Initiation; Calcium dynamics;
Implementer(s): Connelly, William [connelly.bill at gmail.com];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; AMPA; NMDA; I T low threshold; I h; I Calcium; Glutamate;
TITLE transmitter release

COMMENT
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   References:

   Destexhe, A., Mainen, Z.F. and Sejnowski, T.J. Synthesis of models for
   excitable membranes, synaptic transmission and neuromodulation using a 
   common kinetic formalism, Journal of Computational Neuroscience 1: 
   195-230, 1994.

   Destexhe, A., Mainen, Z.F. and Sejnowski, T.J.  Kinetic models of 
   synaptic transmission.  In: Methods in Neuronal Modeling (2nd edition; 
   edited by Koch, C. and Segev, I.), MIT press, Cambridge, 1996.

  Written by Bjoern Kampa, 2004

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ENDCOMMENT


INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX rel
	RANGE T, del, dur, amp
}

UNITS {
	(mM) = (milli/liter)
}

PARAMETER {
	del (ms)
	dur (ms)	<0,1e9>
	amp (mM)
}

ASSIGNED { T (mM)
}


INITIAL {
	T = 0
}

BREAKPOINT {
	at_time(del)
	at_time(del+dur)

	if (t < del + dur && t > del) {
		T = amp
	}else{
		T = 0
	}
}



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