Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)

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Accession:223955
Model of pyramidal neurons that either hyper or hypo excitable due to SCN2A mutations. Mutations are taken from patients with ASD or Epilepsy
Reference:
1 . Ben-Shalom R, Keeshen CM,Berrios KN, An JY, Sanders SJ, Bender KJ (2017) Opposing effects on NaV1.2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures Biological Psychiatry, epub before print
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell;
Channel(s): I Na,t; I Sodium; I K;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.2 SCN2A;
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s):
Implementer(s): Ben-Shalom, Roy [bens.roy at gmail.com];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; I Na,t; I K; I Sodium;
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SCN2A_ASD
Excitability
YoungL1536V
Cad.mod *
CaH.mod *
CaT.mod *
charge.mod *
h.mod *
Kca.mod *
Kv.mod *
Kv1_axonal.mod *
Kv7.mod *
na8st.mod *
na8st1.mod
nax8st.mod *
nax8st1.mod
28_04_10_num19.hoc *
Cell parameters.hoc *
charge.hoc *
mosinit.hoc *
scn2aExps.hoc
                            
TITLE Ih-current

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
     (mM) = (milli/liter)

}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
	dt (ms)
	v (mV)
     eh = -47  (mV) 		:ih-reversal potential by Berger	  
	gbar = 0.00015 (mho/cm2)	:density on dendrite assuming 150pA current and 				150mV driving force (=200pS/um2)
	
}


NEURON {
	SUFFIX ih
	NONSPECIFIC_CURRENT Ih
	RANGE Ih,gbar
}

STATE {
	h
}

ASSIGNED {
	Ih (mA/cm2)
}

INITIAL {
	h=alpha(v)/(beta(v)+alpha(v))
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	Ih = gbar*h*(v-eh)
}

FUNCTION alpha(v(mV)) {
	alpha = 0.001*6.43*(v+154.9)/(exp((v+154.9)/11.9)-1)			:parameters are estimated by direct fitting of HH model to activation time constants and voltage actication curve recorded at  34C by M. Kole
}

FUNCTION beta(v(mV)) {
	beta = 0.001*193*exp(v/33.1)			
}

DERIVATIVE state {     : exact when v held constant; integrates over dt step
	h' = (1-h)*alpha(v) - h*beta(v)
}









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