Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)

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Accession:224923
" ... Here, we performed a detailed investigation of the frequency dependence of the conductivity within cortical tissue at microscopic distances using small current amplitudes within the typical (neuro)physiological micrometer and sub-nanoampere range. We investigated the propagation of LFPs, induced by extracellular electrical current injections via patch-pipettes, in acute rat brain slice preparations containing the somatosensory cortex in vitro using multielectrode arrays. Based on our data, we determined the cortical tissue conductivity over a 100-fold increase in signal frequency (5-500 Hz). Our results imply at most very weak frequency-dependent effects within the frequency range of physiological LFPs. Using biophysical modeling, we estimated the impact of different putative impedance spectra. Our results indicate that frequency dependencies of the order measured here and in most other studies have negligible impact on the typical analysis and modeling of LFP signals from extracellular brain recordings."
Reference:
1 . Miceli S, Ness TV, Einevoll GT, Schubert D (2017) Impedance Spectrum in Cortical Tissue: Implications for Propagation of LFP Signals on the Microscopic Level Eneuro 4:1-15
Model Information (Click on a link to find other models with that property)
Model Type: Extracellular; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Python; NEURON;
Model Concept(s): Extracellular Fields; Methods; Simplified Models; Detailed Neuronal Models;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell; I Na,p; I Na,t; I L high threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
This python package reproduces simulation results from
Miceli, Ness, Einevoll, Schubert (2017)
Impedance Spectrum in Cortical Tissue: Implications for Propagation of LFP Signals on the Microscopic Level.
Eneuro 4:1–15.
http://eneuro.org/content/4/1/ENEURO.0291-16.2016.full.pdf+html

Questions can be addressed to Torbjorn V Ness: torbness@gmail.com

To use run the simulations, the NEURON mechanisms (*.mod) must be compiled.
If NEURON is correctly installed this can be done on Linux and OS X by
opening the folder "hay" in a terminal and writing "nrnivmodl".

You also need LFPy to run the simulations: http://lfpy.github.io/

To reproduce simulation results in Figure 3 and 4, open this folder in a terminal
and write
"python tissue_impedance_impact.py"

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