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Model for K-ATP mediated bursting in mSNc DA neurons (Knowlton et al 2018)
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"Burst firing in medial substantia nigra dopamine (mSN DA) neurons has been selectively linked to novelty-induced exploration behavior in mice. Burst firing in mSN DA neurons, in contrast to lateral SN DA neurons, requires functional ATP-sensitive potassium channels (K-ATP) both in vitro and in vivo. However, the precise role of K-ATP channels in promoting burst firing is un-known. We show experimentally that L-type calcium channel activity in mSN DA neurons en-hances open probability of K-ATP channels. We then generated a mathematical model to study the role of Ca2+ dynamics driving K-ATP channel function in mSN DA neurons during bursting. ..."
Knowlton C, Kutterer S, Roeper J, Canavier CC (2018) Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study.
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Neuron or other electrically excitable cell;
Substantia nigra pars compacta DA cell;
ATP-senstive potassium current;
C or C++ program;
Ion Channel Kinetics;
Knowlton, Christopher [cknow1 at lsuhsc.edu];
for information about:
Substantia nigra pars compacta DA cell
ATP-senstive potassium current
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