Mirror Neuron (Antunes et al 2017)

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Accession:229276
Modeling Mirror Neurons Through Spike-Timing Dependent Plasticity. This script reproduces Figure 3B.
Reference:
1 . Antunes G, Faria da Silva SF, Simoes de Souza FM (2018) Mirror Neurons Modeled Through Spike-Timing-Dependent Plasticity are Affected by Channelopathies Associated with Autism Spectrum Disorder. Int J Neural Syst 28:1750058 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s): I Calcium; I M; I h; I Potassium; I Sodium;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Cav1.2 CACNA1C; Cav1.3 CACNA1D;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; STDP;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  AMPA; NMDA; I M; I h; I Sodium; I Calcium; I Potassium; Glutamate;
/
Final
hoc_recordings
mechanisms
morphology
python_recordings
synapses
README
.provenance.json
biophysics.hoc
cellinfo.json
CHANGELOG
constants.hoc *
creategui.hoc
createsimulation.hoc
current_amps.dat
init_super.hoc
LICENSE *
morphology.hoc
mosinit.hoc
ringplot.hoc *
run.py
run_hoc.sh
run_RmpRiTau.py
template.hoc
VERSION
                            

/*
Copyright (c) 2015 EPFL-BBP, All rights reserved.

THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS''
AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO,
THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR
PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJECT
BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR
BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY,
WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE
OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN
IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.

This work is licensed under a
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
To view a copy of this license, visit
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode or send a letter to
Creative Commons,
171 Second Street, Suite 300,
San Francisco, California, 94105, USA.
*/

/*
 * @file biophys.hoc
 * @brief Biophysics
 * @author Etay Hay, Werner Van Geit @ BBP
 * @date 2015
*/
begintemplate cADpyr232_biophys
public biophys, distribute

public sinapse0, sinapse1, sinapse2
objectvar sinapse0, sinapse1, sinapse2

proc distribute(){local x localobj sl
        strdef stmp,distfunc,mech
        sl = $o1
        mech = $s2
        distfunc = $s3
        sprint(distfunc,"%%s %s(%%f) = %s",mech, distfunc)
        forsec sl for(x) {
            sprint (stmp,distfunc,secname(),x,distance(x))
            execute(stmp)
        }
    }

proc biophys() {
	forsec $o1.basal {
		insert Ih
	}

	forsec $o1.apical {
		insert Im
		insert NaTs2_t
		insert SKv3_1
		insert Ih
	}

	forsec $o1.somatic {
		insert Ca_HVA
		insert SKv3_1
		insert SK_E2
		insert Ca_LVAst
		insert Ih
		insert NaTs2_t
		insert CaDynamics_E2
	}

	forsec $o1.axonal {
		insert Ca_HVA
		insert SKv3_1
		insert SK_E2
		insert CaDynamics_E2
		insert Nap_Et2
		insert K_Pst
		insert K_Tst
		insert Ca_LVAst
		insert NaTa_t
	}

	forsec $o1.all {
		insert pas
	}

	forsec $o1.all {
		e_pas = -75 
	}

	forsec $o1.all {
		Ra = 100 
	}

	forsec $o1.all {
		cm = 1 
	}

	forsec $o1.all {
		g_pas = 3e-5 
	}

	forsec $o1.apical {
		ena = 50 
	}

	forsec $o1.apical {
		ek = -85 
	}

	forsec $o1.apical {
		cm = 2 
	}

	forsec $o1.axonal {
		ena = 50 
	}

	forsec $o1.axonal {
		ek = -85 
	}

	forsec $o1.basal {
		cm = 2 
	}

	forsec $o1.somatic {
		ena = 50 
	}

	forsec $o1.somatic {
		ek = -85 
	}

		distribute($o1.basal,"gIhbar_Ih","(0.0 * %g + 1.0)*0.000080")
		distribute($o1.apical,"gNaTs2_tbar_NaTs2_t","(0.0 * %g + 1.0)*0.026145")
		distribute($o1.apical,"gSKv3_1bar_SKv3_1","(0.0 * %g + 1.0)*0.004226")
		distribute($o1.apical,"gIhbar_Ih","(-0.869600 + 2.087000*exp((%g-0.000000)*0.003100))*0.000080")
		distribute($o1.apical,"gImbar_Im","(0.0 * %g + 1.0)*0.000143")
		distribute($o1.axonal,"gNaTa_tbar_NaTa_t","(0.0 * %g + 1.0)*3.137968")
		distribute($o1.axonal,"gK_Tstbar_K_Tst","(0.0 * %g + 1.0)*0.089259")
		distribute($o1.axonal,"gamma_CaDynamics_E2","(0.0 * %g + 1.0)*0.002910")
		distribute($o1.axonal,"gNap_Et2bar_Nap_Et2","(0.0 * %g + 1.0)*0.006827")
		distribute($o1.axonal,"gSK_E2bar_SK_E2","(0.0 * %g + 1.0)*0.007104")
		distribute($o1.axonal,"gCa_HVAbar_Ca_HVA","(0.0 * %g + 1.0)*0.000990")
		distribute($o1.axonal,"gK_Pstbar_K_Pst","(0.0 * %g + 1.0)*0.973538")
		distribute($o1.axonal,"gSKv3_1bar_SKv3_1","(0.0 * %g + 1.0)*1.021945")
		distribute($o1.axonal,"decay_CaDynamics_E2","(0.0 * %g + 1.0)*287.198731")
		distribute($o1.axonal,"gCa_LVAstbar_Ca_LVAst","(0.0 * %g + 1.0)*0.008752")
		distribute($o1.somatic,"gamma_CaDynamics_E2","(0.0 * %g + 1.0)*0.000609")
		distribute($o1.somatic,"gSKv3_1bar_SKv3_1","(0.0 * %g + 1.0)*0.303472")
		distribute($o1.somatic,"gSK_E2bar_SK_E2","(0.0 * %g + 1.0)*0.008407")
		distribute($o1.somatic,"gCa_HVAbar_Ca_HVA","(0.0 * %g + 1.0)*0.000994")
		distribute($o1.somatic,"gNaTs2_tbar_NaTs2_t","(0.0 * %g + 1.0)*0.983955")
		distribute($o1.somatic,"gIhbar_Ih","(0.0 * %g + 1.0)*0.000080")
		distribute($o1.somatic,"decay_CaDynamics_E2","(0.0 * %g + 1.0)*210.485284")
		distribute($o1.somatic,"gCa_LVAstbar_Ca_LVAst","(0.0 * %g + 1.0)*0.000333")
}

endtemplate cADpyr232_biophys

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