Mirror Neuron (Antunes et al 2017)

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Accession:229276
Modeling Mirror Neurons Through Spike-Timing Dependent Plasticity. This script reproduces Figure 3B.
Reference:
1 . Antunes G, Faria da Silva SF, Simoes de Souza FM (2018) Mirror Neurons Modeled Through Spike-Timing-Dependent Plasticity are Affected by Channelopathies Associated with Autism Spectrum Disorder. Int J Neural Syst 28:1750058 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s): I Calcium; I M; I h; I Potassium; I Sodium;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Cav1.2 CACNA1C; Cav1.3 CACNA1D;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; STDP;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  AMPA; NMDA; I M; I h; I Sodium; I Calcium; I Potassium; Glutamate;
/
Final
hoc_recordings
mechanisms
morphology
python_recordings
synapses
README
.provenance.json
biophysics.hoc
cellinfo.json
CHANGELOG
constants.hoc *
creategui.hoc
createsimulation.hoc
current_amps.dat
init_super.hoc
LICENSE *
morphology.hoc
mosinit.hoc
ringplot.hoc *
run.py
run_hoc.sh
run_RmpRiTau.py
template.hoc
VERSION
                            
/*
Copyright (c) 2015 EPFL-BBP, All rights reserved.

THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS''
AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO,
THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR
PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJECT
BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR
BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY,
WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE
OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN
IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode or send a letter to Creative Commons, 171
Second Street, Suite 300, San Francisco, California, 94105, USA.
*/


/*                                                                               
 * @file creategui.hoc                                                           
 * @brief Draw the GUI                                
 * @author Werner Van Geit @ BBP                                                 
 * @date 2015                                                                    
*/        

load_file("ringplot.hoc")

pwmcnt = PWManager[0].count  // the initial GUIs should not be dismissed

objref mainhbox
objref plotvbox
objref shapehbox
objref synapsevbox
objref synapsevbox_size
objref gV, sP, rP, synapse_plot                                                               


xres = 650
yres = 310  //600
xstart = 600
ystart = 0

proc make_mainwindow() {
    mainhbox = new HBox(3)
    mainhbox.intercept(1)

    mainhbox.adjuster(200)
//    make_runcontrol()

    mainhbox.adjuster(360)
    make_plottingpanel()

    mainhbox.adjuster(250)
    make_synapsepanel($o1)

    mainhbox.adjuster(250)
    mainhbox.intercept(0)   
    mainhbox.full_request(1) 
    mainhbox.map("Main", xstart, ystart, xres, yres)
}

proc make_plottingpanel() {
    plotvbox = new VBox()
    plotvbox.intercept(1)

    plotvbox.adjuster(300)
    make_shapepanel()
    
    plotvbox.adjuster(500)
//    rP = new RingPlot()                                                         

    plotvbox.intercept(0)    
    mainhbox.full_request(1) 
    plotvbox.map("Plotting", 0, 0, -1, -1)
}


proc make_runcontrol() {                                                   
    xpanel("RunControl", 0)                                                     
    xbutton("Init & Run","restart()")                                           
    xbutton("Stop","stoprun=1")                                                 
    xvalue("Total time", "tstop")                                                 
    xvalue("Sim Time","t", 0,"", 0, 1 )                                 
    xvalue("Real Time","realtime", 0,"", 0, 1 )                                 
    xbutton("Quit","quit()")
    
    xlabel("Step current")
    xradiobutton("No step","stepcurrent=\"none\"", 1)                                                                                
    xradiobutton("Step current 1","stepcurrent=\"stepcurrent1\"")            
    xradiobutton("Step current 2","stepcurrent=\"stepcurrent2\"")               
    xradiobutton("Step current 3","stepcurrent=\"stepcurrent3\"")               
    xpanel(1498, 0)
} 
                                                                                
proc make_shapepanel() {                                                                                                                                                                                                     
    shapehbox = new HBox()
    shapehbox.intercept(1)

    shapehbox.adjuster(350)
//    sP = new PlotShape(0)                                                       
 //   sP.variable("soma", "v(0.5)")                                               
//    sP.view(-594.956, -98.0373, 1260.25, 1188.42, 573, 0, 505.92, 592)         
 //   sP.exec_menu("View = plot")                                                  
 //   sP.exec_menu("Shape Plot")                                                  
 //   fast_flush_list.append(sP)

    shapehbox.adjuster(350)                                    
    synapse_plot = new Shape(0)
    synapse_plot.view(-594.956, -98.0373, 1260.25, 1188.42, 49, 0, 500.16, 592)

    synapse_plot.exec_menu("View = plot")
 
    shapehbox.intercept(0)    
    shapehbox.full_request(1) 
    plotvbox.full_request(1) 
    mainhbox.full_request(1) 
    shapehbox.map("Shapes", 1104, 0, -1, -1)                                                          
}                  

proc make_synapsepanel() { local n_of_pre_mtypes, pre_mtype_id localobj active_pre_mtypes, pre_mtype_freqs
    strdef pre_mtype_name

    synapsevbox = new HBox()
    synapsevbox.intercept(1)
    xpanel("Synapses")
    xlabel("Presyn m-types")
    for i=0, $o1.synapses.pre_mtypes.size-1 {
         pre_mtype_id = $o1.synapses.pre_mtypes.x[i]
         pre_mtype_freqs = $o1.synapses.pre_mtype_freqs
         pre_mtype_name = $o1.synapses.id_mtype_map.o(pre_mtype_id).s
         active_pre_mtypes = $o1.synapses.active_pre_mtypes
         xstatebutton(pre_mtype_name, &active_pre_mtypes.x[pre_mtype_id], "cell1[0].synapses.update_synapses(synapse_plot)")
    }
    xpanel(100, 0)

    xpanel("Freq")
    xlabel("Frequency (Hz)")
    for i=0, $o1.synapses.pre_mtypes.size-1 {
         pre_mtype_id = $o1.synapses.pre_mtypes.x[i]
         pre_mtype_freqs = $o1.synapses.pre_mtype_freqs
         pre_mtype_name = $o1.synapses.id_mtype_map.o(pre_mtype_id).s
         active_pre_mtypes = $o1.synapses.active_pre_mtypes
         xpvalue("", &pre_mtype_freqs.x[pre_mtype_id], 0, "cell1[0].synapses.update_synapses(synapse_plot)", 1)
    }
    xpanel(100, 0)

    synapsevbox.intercept(0)

    show_synapsepanel()
}

proc show_synapsepanel() {
    if (synapses_enabled == 1) {
        synapsevbox.map("Presynaptic activity", 0, 0, -1, -1)
    } else {
        synapsevbox.unmap()
    }
}

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