Mirror Neuron (Antunes et al 2017)

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Accession:229276
Modeling Mirror Neurons Through Spike-Timing Dependent Plasticity. This script reproduces Figure 3B.
Reference:
1 . Antunes G, da Silva SFF, de Souza FMS (2017) Mirror Neurons Modeled Through Spike-Timing-Dependent Plasticity are Affected by Channelopathies Associated with Autism Spectrum Disorder. Int J Neural Syst :1750058 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s): I Calcium; I M; I h; I Potassium; I Sodium;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Cav1.2 CACNA1C; Cav1.3 CACNA1D;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; STDP;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  AMPA; NMDA; I M; I h; I Sodium; I Calcium; I Potassium; Glutamate;
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Final
mechanisms
Ca_HVA.mod *
Ca_LVAst.mod *
CaDynamics_E2.mod *
Ih.mod *
Im.mod *
K_Pst.mod *
K_Tst.mod *
Nap_Et2.mod *
NaTa_t.mod *
NaTs2_t.mod *
ProbAMPANMDA_EMS.mod *
ProbGABAAB_EMS.mod *
SK_E2.mod *
SKv3_1.mod *
STDP_triplet.mod
Ca_HVA.c
Ca_HVA.o
Ca_LVAst.c
Ca_LVAst.o
CaDynamics_E2.c
CaDynamics_E2.o
Ih.c
Ih.o
Im.c
Im.o
K_Pst.c
K_Pst.o
K_Tst.c
K_Tst.o
mod_func.c
mod_func.o
Nap_Et2.c
Nap_Et2.o
NaTa_t.c
NaTa_t.o
NaTs2_t.c
NaTs2_t.o
nrnmech.dll
ProbAMPANMDA_EMS.c
ProbAMPANMDA_EMS.o
ProbGABAAB_EMS.c
ProbGABAAB_EMS.o
SK_E2.c
SK_E2.o
SKv3_1.c
SKv3_1.o
STDP_triplet.c
STDP_triplet.o
                            
: Dynamics that track inside calcium concentration
: modified from Destexhe et al. 1994

NEURON	{
	SUFFIX CaDynamics_E2
	USEION ca READ ica WRITE cai
	RANGE decay, gamma, minCai, depth
}

UNITS	{
	(mV) = (millivolt)
	(mA) = (milliamp)
	FARADAY = (faraday) (coulombs)
	(molar) = (1/liter)
	(mM) = (millimolar)
	(um)	= (micron)
}

PARAMETER	{
	gamma = 0.05 : percent of free calcium (not buffered)
	decay = 80 (ms) : rate of removal of calcium
	depth = 0.1 (um) : depth of shell
	minCai = 1e-4 (mM)
}

ASSIGNED	{ica (mA/cm2)}

STATE	{
	cai (mM)
	}

BREAKPOINT	{ SOLVE states METHOD cnexp }

DERIVATIVE states	{
	cai' = -(10000)*(ica*gamma/(2*FARADAY*depth)) - (cai - minCai)/decay
}

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