Hyperbolic model (Daneshzand et al 2017)

 Download zip file 
Help downloading and running models
Accession:230562
A modified Izhikevich neuron model to address the switching patterns of neuronal firing seen in Parkinson's Disease.
Reference:
1 . Daneshzand M, Faezipour M, Barkana BD (2017) Hyperbolic Modeling of Subthalamic Nucleus Cells to Investigate the Effect of Dopamine Depletion. Comput Intell Neurosci 2017:5472752 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Subthalamic Nucleus;
Cell Type(s): Abstract Izhikevich neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: MATLAB;
Model Concept(s): Action Potentials;
Implementer(s): Daneshzand, Mohammad [mdaneshz at my.bridgeport.edu];
Search NeuronDB for information about:  Dopamine;
/
DaneshzandEtAl2017
readme.html
code.m
screenshot.png
                            
close all; clc; clear all;
%%%%%%% DAneshzand  spiking neuron model %%%%%%%%%
%%%%%%%%%%%%%%%%%% 10/12/2017 %%%%%%%%%%%%%%
Parameters = [0.02 0.2 -65 6];
V=-70;  u=Parameters(2)*V;
VV=[];  uu=[];
tau = 0.25; tspan = 0:tau:100;
T1=tspan(end)/10;
for t=tspan
    if (t>T1) 
        I=14;
    else
        I=0;
    end;
    V = V + tau*(75000*(cosh((V+62.5)./1000)-1)-16-u+I);
    u = u + tau*Parameters(1)*(Parameters(2)*V-u);
    if V > 30
        VV(end+1)=30;
        V = Parameters(3);
        u = u + Parameters(4);
    else
        VV(end+1)=V;
    end;
    uu(end+1)=u;
end;
plot(tspan,VV,[0 T1 T1 max(tspan)],-90+[0 0 10 10]);
axis([0 max(tspan) -90 30])
xlabel('time');ylabel('membrane potential');
title('tonic spike');

Loading data, please wait...