The cannula artifact (Chandler & Hodgkin 1965)

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Accession:230888
Chandler and Hodgkin 1965 describes how using a high impedance electrode can lead to squid axon recordings that appear to overshoot the sodium reversal potential, thus resolving controversial recordings at the time.
Reference:
1 . Chandler WK, Hodgkin AL (1965) The effect of internal sodium on the action potential in the presence of different internal anions. J Physiol 181:594-611 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Squid axon;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Methods; Action Potentials; Tutorial/Teaching;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
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ChandlerHodgkin1965
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chandler1.ses
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Chandler WK, Hodgkin AL (1965) The effect of internal sodium on the action potential in the presence of different internal anions. J Physiol 181:594-611[PubMed]

References and models cited by this paper

References and models that cite this paper

ADELMAN WJ, FOK YB (1964) INTERNALLY PERFUSED SQUID AXONS STUDIED UNDER VOLTAGE CLAMP CONDITIONS. II. RESULTS. THE EFFECTS OF INTERNAL POTASSIUM AND SODIUM ON MEMBRANE ELECTRICAL CHARACTERISTICS. J Cell Comp Physiol 64:429-43 [PubMed]

BAKER PF, HODGKIN AL, MEVES H (1964) THE EFFECT OF DILUTING THE INTERNAL SOLUTION ON THE ELECTRICAL PROPERTIES OF A PERFUSED GIANT AXON. J Physiol 170:541-60 [PubMed]

BAKER PF, HODGKIN AL, SHAW TI (1962) Replacement of the axoplasm of giant nerve fibres with artificial solutions. J Physiol 164:330-54 [PubMed]

BAKER PF, HODGKIN AL, SHAW TI (1962) The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons. J Physiol 164:355-74 [PubMed]

Chandler WK, Meves H (1965) Voltage clamp experiments on internally perfused giant axons. J Physiol 180:788-820 [PubMed]

Chandler WK,Meves H (1964) Voltage-clamp experiments on perfused giant axons J. Physiol. 173:31-32 [Journal]

Goldman DE (1943) POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES. J Gen Physiol 27:37-60 [PubMed]

HODGKIN AL, KATZ B (1949) The effect of sodium ions on the electrical activity of giant axon of the squid. J Physiol 108:37-77 [PubMed]

MOORE JW, NARAHASHI T, ULBRICHT W (1964) SODIUM CONDUCTANCE SHIFT IN AN AXON INTERNALLY PERFUSED WITH A SUCROSE AND LOW-POTASSIUM SOLUTION. J Physiol 172:163-73 [PubMed]

ROBINSON RA,STOKES RH (1959) Electrolyte Solutions 2nd Ed.

TASAKI I, LUXORO M (1964) INTRACELLULAR PERFUSION OF CHILEAN GIANT SQUID AXONS. Science 145:1313-5 [PubMed]

TASAKI I, TAKENAKA T (1963) RESTING AND ACTION POTENTIAL OF SQUID GIANT AXONS INTRACELLULARLY PERFUSED WITH SODIUM-RICH SOLUTIONS. Proc Natl Acad Sci U S A 50:619-26 [PubMed]

TASAKI I, TAKENAKA T (1964) EFFECTS OF VARIOUS POTASSIUM SALTS AND PROTEASES UPON EXCITABILITY OF INTRACELLULARLY PERFUSED SQUID GIANT AXONS. Proc Natl Acad Sci U S A 52:804-10 [PubMed]

TASAKII , WATANABE A, TAKENAKA T (1962) Resting and action potential of intracellularly perfused squid giant axon. Proc Natl Acad Sci U S A 48:1177-84 [PubMed]

(14 refs)