Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

 Download zip file 
Help downloading and running models
Accession:231416
We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;
//genesis

/***************************		MS Model, Version 5.10	**********************
**************************** 	      	globals.g 			**********************
Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
*******************************************************************************
	The capatilized parameters defined below are global and visable to all files
	Capatilized parameters should be treated as constants
******************************************************************************/
/* AB: Comments indicate the qfactor used with the various channels
*  conductance of CaN and CaL12 sum the inactivating and non-inactivating channel
*  conductances from the previous model
*/
        float ELEAK = -0.070
        float PI = 3.1415926
        float RA = 1.0;
        float RM = 8.69565217;
        float CM = 0.01;
        float EREST_ACT = -0.08
 	float TEMPERATURE = 35
        float temperature = 35   // some old MS commands need it
	str  CA_BUFF_1 = "Ca_difshell_1"     // L and T type channels
	str  CA_BUFF_2 = "Ca_difshell_2"     // coupled to the other channels
	str  CA_BUFF_3 = "Ca_difshell_3"     // all calcium channels
	
	int CaDyeFlag = 0    // flags of calcium dye. "0" means NO calcium dyes.
                     // flag =2 : Fluo-4
                     // flag =3 : Fluo-5F
	int shellMode = 1     // we  have two shell-modes:
                     //  mode = 0 : detailed multi-shell model, using "difshell" object
                     //  mode = 1 : simple calcium pool adopted from  Sabatini's work(Sabatini, 2001, 2004)

//parameters determined by hand tuning to match spike width, AHP shape &amp, fI curve
//spike width with these globals plus spines = 0.88 ms
        str gNaFprox={90000}*1  //qfactor = 1.2   90000
        str gNaFmid={975}*0.1
        str gNaFdist={975}*0.1

        str gKAfprox={3214}*1   //qfactor=1.5 for inact
        str gKAfmid={471}*1   //1/qfactor=1.5 for act!!!
        str gKAfdist={314}*0.3

        str gKAsprox={277}*0.5   //qfactor=2	 
        str gKAsdist={22.9}*0.5

        str gKIRsoma= 4.2*4          //qfactor = 0.5;   gKIR=4.2
        str gKIRdist= 4.2*4
        str gKDR={7.25}*1      //qfactor = 0.5  

	float gCaL13 = 1.0625e-7  //qfactor=2
	float gCaT  =  0.5875e-8
	float gCaR  =  6.5e-7
//	float gCaQ  =  1.5e-7
	float gCaN =   2.5e-7       //qfactor=2
	float gCaL12 = 0.8375e-7    //qfactor=2



Loading data, please wait...