Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

 Download zip file 
Help downloading and running models
Accession:231416
We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;
/
MSN
MScell
channels
.directory
.goutputstream-A48NIW
.goutputstream-JLG4IW
ampa_channel.g *
BKKchannel.g
CaL12inact_channel.g
CaL13_channel.g
CaNinact_channel.g
CaR_channel.g
CaT_channel.g
gaba_channel.g
K_DR_channel.g
kAf_chanRE.g
kAs_chanKD.g
kAs_chanRE.g
kIR_chanKD.g
naF_chanOg.g
NaP_channel.g
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis
//nmda_channel.g

function make_NMDA_channel (chanpath, Ek, KMg, tau2, gmax, ghk)

  str chanpath //what you want the channel to be called (full path)
  float KMg, tau2, gmax  //parameters that differ between NR2A, B, C and D subunits
  
  float Ek
  int ghk 
  
  float tau1 = (4.4624e-3)/2 //  DE Chapman et al 2003, table 1 (12.13/e=5.63ms)
  float CMg = 1  // [Mg] in mM

  float eta = 1/3.57  // per mM
  float gamma = 62  // per Volt

	echo "XXXXXXXXXXXXXXX make_NMDA_channel XXXXXXXXXXXXXXXX"
	echo "chanpath = "{chanpath}
	echo "caBuffer = "{Ek}
	echo "KMg = "{KMg}
	echo "tau2 = "{tau2}
	echo "gmax = "{gmax}
	echo "XXXXXXXXXXXXXXX make_NMDA_channel XXXXXXXXXXXXXXXX"

	create synchan {chanpath}
	setfield {chanpath} \
          Ek   {Ek}   \
          tau1 {tau1} \
          tau2 {tau2} \
          gmax {gmax/2}
   
//the kinetics of the magnesium block is different for different subunits.  
// NR2A and B are about the same, but C and D are much less affected by the block.  
//these numbers were used because the made the magnesium block curve fit the figures by Moyner et al (1994 figure 7) best by eye.

  create Mg_block {chanpath}/block
  setfield {chanpath}/block CMg {CMg} 
  setfield {chanpath}/block KMg_B {1.0/{gamma}}
  setfield {chanpath}/block KMg_A {KMg}
				
  addmsg {chanpath} {chanpath}/block CHANNEL Gk Ek

  if (ghk==1)
     create ghk {chanPath}/GHK
     setfield {chanPath}/GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, Wolf 5mM
     setfield {chanPath}/GHK valency 2.0
     setfield {chanPath}/GHK T {temperature}
     addmsg {compPath}/{chanpath}/block {chanPath}/GHK PERMEABILITY Gk 
  end

end


Loading data, please wait...