Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

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Accession:231416
We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Reference:
1 . Du K, Wu YW, Lindroos R, Liu Y, Rózsa B, Katona G, Ding JB, Kotaleski JH (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proc Natl Acad Sci U S A 114:E7612-E7621 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s): Cav3.2 CACNA1H;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: GENESIS;
Model Concept(s):
Implementer(s): Du, Kai [kai.du at ki.se];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I Calcium; I A, slow; I R; I Q; Kir; Gaba; Glutamate;
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MSN
MScell
channels
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.goutputstream-A48NIW
.goutputstream-JLG4IW
ampa_channel.g *
BKKchannel.g
CaL12inact_channel.g
CaL13_channel.g
CaNinact_channel.g
CaR_channel.g
CaT_channel.g
gaba_channel.g
K_DR_channel.g
kAf_chanRE.g
kAs_chanKD.g
kAs_chanRE.g
kIR_chanKD.g
naF_chanOg.g
NaP_channel.g
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
/*form call file for creating tab channels*/


function exp_form (rate, slope, V)
	float rate,slope,V
	//equation is ({rate} *(exp (-{V}/{slope}) ))
	float numx ={{-V}/{slope}}
	float expx = {exp {numx}}
	float entry = ({rate}*{expx})
	return {entry}
end

function sig_form (rate, vhalf, slope, V)
	float rate, vhalf, slope, V
	//equation is ({rate}/(exp ({{V}-{vhalf}}/{slope})+1))
	//rate/(EXP((v-vhalf)/slope)+1)
	float numx = {{{V}-{vhalf}}/{slope}}
	float expx = {exp {numx}}
	float entry = ({rate}/{{expx}+1})
	return {entry}
end

function lin_form (rate, vhalf, slope, V)

	float rate, vhalf, slope, V
	//equation is (({rate}*({V}-{vhalf}))/{exp ({v}-{vhalf}/{slope})-1)})
	float numx = {{{{V}-{vhalf}}/{slope}}-1}
	float expx = {exp {numx}}
	float numerator = {{rate}*{{V}-{vhalf}}}
	float entry = {{numerator}/{expx}}
	return {entry}
	// put in check for if v=vhalf then add 0.0001 or something. or... dtop/dbottom is L'Hopital.  
	
end

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