Behavioral time scale synaptic plasticity underlies CA1 place fields (Bittner et al. 2017)


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Accession:232074
" ... Place fields could be produced in vivo in a single trial by potentiation of input that arrived seconds before and after complex spiking.The potentiated synaptic input was not initially coincident with action potentials or depolarization.This rule, named behavioral timescale synaptic plasticity, abruptly modifies inputs that were neither causal nor close in time to postsynaptic activation. ...", " ... To determine if the above plasticity rule could be observed under more realistic model conditions, we constructed and optimized a biophysically detailed model and attempted to fully account for the experimental data. ... "
Reference:
1 . Bittner KC, Milstein AD, Grienberger C, Romani S, Magee JC (2017) Behavioral time scale synaptic plasticity underlies CA1 place fields. Science 357:1033-1036 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model);
Model Concept(s): Hebbian plasticity; Action Potentials; Synaptic Plasticity; Calcium dynamics; Learning; Place cell/field;
Implementer(s): Milstein, Aaron D. ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
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Bittner KC, Milstein AD, Grienberger C, Romani S, Magee JC (2017) Behavioral time scale synaptic plasticity underlies CA1 place fields. Science 357:1033-1036[PubMed]

References and models cited by this paper

References and models that cite this paper

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