The role of glutamate in neuronal ion homeostasis: spreading depolarization (Hubel et al 2017)

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Accession:235774
This model includes ion concentration dynamics (sodium, potassium, chloride) inside and outside the neuron, the exchange of ions with glia and blood vessels, volume dynamics of neuron, glia, and extracellular space, glutamate homeostasis involving release by neuron and uptake by both neuron and glia. Spreading depolarization is used as a case study.
Reference:
1 . Hübel N, Hosseini-Zare MS, Žiburkus J, Ullah G (2017) The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization. PLoS Comput Biol 13:e1005804 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Generic; Neocortex;
Cell Type(s): Astrocyte;
Channel(s): I Potassium; I Sodium; I Cl, leak; I K,leak; I Na, leak; Na/K pump;
Gap Junctions:
Receptor(s): AMPA; Glutamate;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: XPP;
Model Concept(s): Action Potentials; Homeostasis;
Implementer(s): Ullah, Ghanim [ghanim.phy at gmail.com]; Hubel, Niklas ;
Search NeuronDB for information about:  AMPA; Glutamate; I K,leak; I Sodium; I Potassium; Na/K pump; I Cl, leak; I Na, leak; Glutamate;
 
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HubelEtAl2017
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