Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)

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Accession:236310
This model achieves electrotonic transform and computes mean inward and outward attenuation from 0 to 500 Hz input; and randomly activates synapses along dendrites to simulate AMPAR mediated EPSCs. For electrotonic analysis, in Elec folder, the entry file is MSNelec_transform.hoc. For EPSC simulation, in Syn folder, the entry file is randomepsc.hoc. Run read_EPSCsims_mdb_alone.m next with the simulated parameter values specified to compute the mean EPSC.
Reference:
1 . Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI (2018) Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One 13:e0200626 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Membrane Properties; Electrotonus; Synaptic-input statistic;
Implementer(s):
Search NeuronDB for information about:  AMPA;
/
GoodliffeEtAl2018
Syn
tau_tables
bkkca.mod
cadyn.mod *
caL.mod
caL13.mod
caldyn.mod
can.mod
caq.mod *
car.mod
cat.mod
kaf.mod
kas.mod
kdr.mod
kir.mod *
krp.mod *
linearIclamp.mod
naf.mod
nap.mod
skkca.mod
stim.mod *
actionPotentialPlayer.hoc *
all_tau_vecs.hoc
analyticFunctions.hoc *
analyze_EPSC.m
aux_procs.hoc
baseline_values.txt
basic_procs.hoc
createFit_WTD1.m
electro_procs.hoc
fixnseg.hoc *
load_scripts.hoc
msp_template.hoc
PFC-V1_AddSynapses.hoc
PFC-V1_AddSynapses_fix.hoc
PFC-V1_AddSynapses_neg.hoc
PFC-V1_AddSynapses_negexp.hoc
plot_seClamp_i.ses
ran_test.hoc
randomepsc.hoc
ranstream.hoc
read_EPSCsims_mdb_alone.m
readcell.hoc
readNRNbin_Vclamp.m
                            
TITLE Fast A-type Potassium current for nucleus accumbens (Kv4.2)

COMMENT
Jason Moyer 2004 - jtmoyer@seas.upenn.edu

Tkatch, T., Baranauskas, G., and Surmeier, D. J. (2000). Kv4.2 mRNA
abundance and A-type K(+) current amplitude are linearly related in
basal ganglia and basal forebrain neurons. J Neurosci 20, 579-588.

22 degrees

ENDCOMMENT

UNITS {
	(mV) = (millivolt)
	(mA) = (milliamp)
	(S) = (siemens)
}

NEURON {
	SUFFIX kaf
	USEION k READ ek WRITE ik
	RANGE gkbar, ik, mshift, hshift
}

PARAMETER {
	gkbar = 0.02	(S/cm2)		: 0.21 in soma and prox; 0.019211 in mid/dist dends

	mvhalf = -10.0	(mV)		: Tkatch 2000 pg 581
	mslope = -17.7	(mV)		: Tkatch 2000 pg 581 - need to use -17.7, not 17.7
	mshift = 10.801	(mV)
	
	hvhalf = -75.6	(mV)		: Tkatch 2000 pg 582
	hslope	= 10	(mV)		: match to Tkatch 2000 fig 3B
	hshift = 14.848	(mV)
	htau = 14	(ms)			: Tkatch 2000 Fig 3C

	qfact = 0.5
	power = 2
}

ASSIGNED { 
	v 		(mV)
    ik 		(mA/cm2)
	ek 		(mV)

	minf
	hinf
}

STATE {
    m h
}

BREAKPOINT {
    SOLVE states METHOD cnexp
	ik  = gkbar * m^power * h * (v-ek)
}

INITIAL {
	rates(v)
	m = minf
	h = hinf
}

FUNCTION_TABLE mtau (v(mV))  (ms)	: Tkatch 2000 Fig 2B

DERIVATIVE states {  
	rates(v)
	m' = (minf - m) / (mtau(v) / qfact)
	h' = (hinf - h) / (htau / qfact)
}


PROCEDURE rates( v(mV) ) {  : Boltzman adjusted to give proper Erev dependency 
	TABLE minf, hinf DEPEND mshift, hshift, hslope
		FROM -200 TO 200 WITH 201
			minf = 1  /  ( 1 + exp( (v - mvhalf - mshift) / mslope) ) 
			hinf = 1  /  ( 1 + exp( (v - hvhalf - hshift) / hslope) ) 
}



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